ArticleProceedings of the National Academy of Sciences of the United States of America1995
Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynamin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 72 citations in OpenAlex.
- The Effect of Alendronate on Osteoclastogenesis in Different Combinations of M-CSF and RANKL Growth Factors.Biomolecules · 2021Article
- Impaired Focal Adhesion Kinase-Grb2 Interaction during Elevated Activity in Hippocampal Neurons.International journal of molecular sciences · 2015Article
- Role of dynamin 2 in the disassembly of focal adhesions.Journal of molecular medicine (Berlin, Germany) · 2013Review
- A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src.Molecular biology of the cell · 2011Article
- Article
- Dynamin 2 and human diseases.Journal of molecular medicine (Berlin, Germany) · 2010Review
- Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues.Arthritis research & therapy · 2007Article
- Fibronectin bound to the surface of Staphylococcus aureus induces association of very late antigen 5 and intracellular signaling factors with macrophage cytoskeleton.Infection and immunity · 2003Article
- An efficient and robust statistical modeling approach to discover differentially expressed genes using genomic expression profiles.Genome research · 2001Article
- Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.Oncogene · 1999Article
- Glomerular overexpression and increased tyrosine phosphorylation of focal adhesion kinase p125FAK in lupus-prone MRL/MP-lpr/lpr mice.Immunology · 1999Article
- Gi-mediated tyrosine phosphorylation of Grb2 (growth-factor-receptor-bound protein 2)-bound dynamin-II by lysophosphatidic acid.The Biochemical journal · 1999Article
- Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells.Molecular biology of the cell · 1997Article
- Expression and activation of SH2/PTB-containing ShcA adaptor protein reflects the pattern of neurogenesis in the mammalian brain.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases.Molecular and cellular biology · 1996Article
- The vitronectin receptor (alpha V beta 3) as an example for the role of integrins in T lymphocyte stimulation.Immunologic research · 1996Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Macrophage colony-stimulating factor (M-CSF) is required for the growth and differentiation of mononuclear phagocytes. In the present studies using human monocytes, we show that M-CSF induces interaction of the Grb2 adaptor protein with the focal adhesion kinase pp125FAK. The results demonstrate that tyrosine-phosphorylated pp125FAK directly interacts with the SH2 domain of Grb2. The findings indicate that a pYENV site at Tyr-925 in pp125FAK is responsible for this interaction. We also demonstrate that the Grb2-FAK complex associates with the GTPase dynamin. Dynamin interacts with the SH3 domains of Grb2 and exhibits M-CSF-dependent tyrosine phosphorylation in association with pp125FAK. These findings suggest that M-CSF-induced signaling involves independent Grb2-mediated pathways, one leading to Ras activation and another involving pp125FAK and a GTPase implicated in receptor internalization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.