ArticleProceedings of the National Academy of Sciences of the United States of America1995
Integration of transplanted hepatocytes into host liver plates demonstrated with dipeptidyl peptidase IV-deficient rats.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 139 citations in OpenAlex.
- Article
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- Decellularized human placenta supports hepatic tissue and allows rescue in acute liver failure.Hepatology (Baltimore, Md.) · 2018Article
- Wilson's disease: Prospective developments towards new therapies.World journal of gastroenterology · 2017Review
- Cell and tissue engineering for liver disease.Science translational medicine · 2014Review
- Cell therapy to remove excess copper in Wilson's disease.Annals of the New York Academy of Sciences · 2014Review
- Effect of Liver Cell Transplantation on Acute Hepatic Failure Induced by Massive Liver Resection in the Rat.Korean journal of hepato-biliary-pancreatic surgery · 2011Article
- Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice.The American journal of pathology · 2009Article
- Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions.Nature medicine · 2004Article
- Quantitative gene expression analysis reveals transition of fetal liver progenitor cells to mature hepatocytes after transplantation in uPA/RAG-2 mice.The American journal of pathology · 2003Article
- Cell transplantation after oxidative hepatic preconditioning with radiation and ischemia-reperfusion leads to extensive liver repopulation.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- A growth-constrained environment drives tumor progression invivo.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine.The American journal of pathology · 1998Article
- Evaluation of the differentiation potential of WB-F344 rat liver epithelial stem-like cells in vivo. Differentiation to hepatocytes after transplantation into dipeptidylpeptidase-IV-deficient rat liver.The American journal of pathology · 1997Article
- Differentiation of pancreatic epithelial progenitor cells into hepatocytes following transplantation into rat liver.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Cell therapy for the diseased liver: from stem cell biology to novel models for hepatotropic human pathogens.Disease models & mechanismsArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
To analyze mechanisms of liver repopulation, we transplanted normal hepatocytes into syngeneic rats deficient in dipeptidyl peptidase IV activity. When isolated hepatocytes were injected into splenic pulp, cells promptly migrated into hepatic sinusoids. To examine whether transplanted hepatocytes entered liver plates and integrated with host hepatocytes, we analyzed sharing of hepatocyte-specific gap junctions and bile canaliculi. Colocalization studies showed gap junctions uniting adjacent transplanted and host hepatocytes in liver plates. Visualization of bile canalicular domains in transplanted and host hepatocytes with dipeptidyl peptidase IV and ATPase activities, respectively, demonstrated hybrid bile canaliculi, which excreted a fluorescent conjugated bile acid analogue. These results indicate that transplanted hepatocytes swiftly overcome mechanical barriers in hepatic sinusoids to enter liver plates and join host cells. Integration into liver parenchyma should physiologically regulate the function or disposition of transplanted hepatocytes and benefit applications such as gene therapy.
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