ArticleThe Journal of experimental medicine1995
Human CD8 transgene regulation of HLA recognition by murine T cells.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Structure, function, and immunomodulation of the CD8 co-receptor.Frontiers in immunology · 2024Review
- Peptide-Based Vaccines for Tuberculosis.Frontiers in immunology · 2022Review
- Molecular mimicry: its evolution from concept to mechanism as a cause of autoimmune diseases.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2014Article
- HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 monochain transgenic/H-2 class I null mice: novel versatile preclinical models of human T cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Opposing chemokine gradients control human thymocyte migration in situ.The Journal of clinical investigation · 2013Article
- Beyond HLA-A*0201: new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Effective elicitation of human effector CD8+ T Cells in HLA-B*51:01 transgenic humanized mice after infection with HIV-1.PloS one · 2012Article
- Article
- Optimization of a self antigen for presentation of multiple epitopes in cancer immunity.The Journal of clinical investigation · 2006Article
- Molecular mimicry, microbial infection, and autoimmune disease: evolution of the concept.Current topics in microbiology and immunology · 2005Review
- Poor immunogenicity of a self/tumor antigen derives from peptide-MHC-I instability and is independent of tolerance.The Journal of clinical investigation · 2004Article
- Effect of the V3 loop deletion of envelope glycoprotein on cellular responses and protection against challenge with recombinant vaccinia virus expressing gp160 of primary human immunodeficiency virus type 1 isolates.Journal of virology · 2002Article
- Differential long-term and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Dense bodies of human cytomegalovirus induce both humoral and cellular immune responses in the absence of viral gene expression.Journal of virology · 2000Article
- Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes.The Journal of experimental medicine · 1997Article
- Glu227-->Lys substitution in the acidic loop of major histocompatibility complex class I alpha 3 domain distinguishes low avidity CD8 coreceptor and avidity-enhanced CD8 accessory functions.The Journal of experimental medicine · 1996Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
A series of human CD8 transgenic (hCD8 Tg) mice with differential expression in the thymus and periphery were produced to investigate CD8 coreceptor regulation of repertoire selection and T cell responses. Expression of hCD8 markedly enhanced responses to both HLA class I molecules and hybrid A2/Kb molecules providing functional evidence for a second interaction site, outside of the alpha 3 domain, which is essential for optimal coreceptor function. Peripheral T cell expression of hCD8 was sufficient to augment responsiveness to HLA class I, as hCD8 Tg mice which lacked thymic expression responded as well as mice expressing hCD8 in the thymus and periphery. Both murine CD8+ and CD4+ T cells expressing hCD8 transgenes exhibited markedly enhanced responses to foreign HLA class I, revealing the ability of T cell receptor repertoires selected on either murine class I or class II to recognize human class I major histocompatibility complex (MHC). In contrast to recognition of foreign class I, thymic expression of hCD8 transgenes was absolutely required to enhance recognition of antigenic peptide restricted by self-HLA class I. Thus, our studies revealed disparate requirements for CD8 coreceptor expression in the thymus for selection of a T cell repertoire responsive to foreign MHC and to antigenic peptides bound to self-MHC, providing a novel demonstration of positive selection that is dependent on human CD8.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.