ArticleThe Journal of experimental medicine1995
Interaction between CD8 and major histocompatibility complex (MHC) class I mediated by multiple contact surfaces that include the alpha 2 and alpha 3 domains of MHC class I.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 93 citations in OpenAlex.
- Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells.Science (New York, N.Y.) · 2024Article
- New insight into the role of fibroblasts in the epithelial immune microenvironment in the single-cell era.Frontiers in immunology · 2023Review
- Single-Cell Transcriptional Analysis Deciphers the Inflammatory Response of Skin-Resident Stromal Cells.Frontiers in surgery · 2022Review
- Single cell transcriptional zonation of human psoriasis skin identifies an alternative immunoregulatory axis conducted by skin resident cells.Cell death & disease · 2021Article
- HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 monochain transgenic/H-2 class I null mice: novel versatile preclinical models of human T cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Phylogenetic and developmental study of CD4, CD8 α and β T cell co-receptor homologs in two amphibian species, Xenopus tropicalis and Xenopus laevis.Developmental and comparative immunology · 2011Article
- Novel nonclassical MHC class Ib genes associated with CD8 T cell development and thymic tumors.Molecular immunology · 2009Article
- Molecular characterization of major histocompatibility complex class I genes from the giant panda (Ailuropoda melanoleuca).Immunogenetics · 2008Article
- Polymorphism of two very similar MHC class Ib loci in rainbow trout (Oncorhynchus mykiss).Immunogenetics · 2006Article
- Interchromosomal duplication of major histocompatibility complex class I regions in rainbow trout (Oncorhynchus mykiss), a species with a presumably recent tetraploid ancestry.Immunogenetics · 2005Article
- In vivo study of the GC90/IRIV vaccine for immune response and autoimmunity into a novel humanised transgenic mouse.British journal of cancer · 2003Article
- Familial CD8 deficiency due to a mutation in the CD8 alpha gene.The Journal of clinical investigation · 2001Article
- Molecular analysis of protein interactions mediating the function of the cell surface protein CD8.Immunologic research · 1999Review
- Assembly and crystallization of the complex between the human T cell coreceptor CD8alpha homodimer and HLA-A2.Protein science : a publication of the Protein Society · 1998Article
- HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice.The Journal of experimental medicine · 1997Article
- CD8 lineage commitment in the absence of CD8.Immunity · 1997Article
- Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes.The Journal of experimental medicine · 1997Article
- Glu227-->Lys substitution in the acidic loop of major histocompatibility complex class I alpha 3 domain distinguishes low avidity CD8 coreceptor and avidity-enhanced CD8 accessory functions.The Journal of experimental medicine · 1996Article
- Human CD8 transgene regulation of HLA recognition by murine T cells.The Journal of experimental medicine · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cell surface glycoprotein CD8 functions as a coreceptor with the TCR on cytotoxic T lymphocytes. Mutational analysis of the binding site of CD8 for MHC class I predicted that distinct surfaces of CD8 would interact with both the alpha 2 and alpha 3 domains of class I. Using a cell-cell adhesion assay, we identified three residues Q115, D122, and E128 in the alpha 2 domain of class I critical for interaction with CD8. The side chains of these residues point towards a cavity formed by the alpha 1/alpha 2 platform, the alpha 3 domain and beta 2-microglobulin (beta 2m) of class I. These residues were predicted to contact CD8 based on a bivalent model of interaction between one CD8 alpha/alpha homodimer and two MHC class I molecules. These results therefore provide support for the model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.