ArticleJournal of endocrinological investigation1995
Effects of acute administration of growth hormone-releasing hormone (GHRH) and oxytocin on somatotroph cells in sheep: morphometric study and growth hormone (GH) secretion.
Article in Journal of endocrinological investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 6 citations in OpenAlex.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, the combined use of the morphometric study of somatotroph cells and plasma GH levels provided new data for the interpretation of the role played by OT and GHRH on GH cells. GHRH 1-29 (15 micrograms/kg), oxytocin (2.5 IU animal) or 1 ml saline solution were administered to male lambs. The GH plasma concentration was measured by RIA and for the morphometric study the cellular area, nuclear area and volume density of the somatotroph cells were measured in 1 micron semi-thin sections immunolabeled with avidin-biotin technique (ABC). The area under the GH response curve for 3 hours after injection was similar in both saline and OT-treated animals (24.8 +/- 9.1 and 31.4 +/- 14.7 micrograms/ml, respectively) and much lower than that observed in GHRH-treated animals (445.5 +/- 126.7 micrograms/ml). The cell area of somatotrophs was smaller in the GHRH-treated lambs and larger in the OT-treated lambs than in the control lambs (71.47 +/- 1.56, 91.42 +/- 1.72 and 83.1 +/- 1.74 microns 2, respectively). A similar change was observed in the nuclear area; it decreased in the GHRH-treated lambs (21.61 +/- 0.52 microns 2) and increased in the OT-treated lambs (25.45 +/- 0.68 microns 2) with respect to the control group (23.75 +/- 0.44 microns 2). No significant differences were found in volume density.(ABSTRACT TRUNCATED AT 250 WORDS)
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Registered trials
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