ArticleThe Journal of clinical investigation1995
Expression of a constitutive NF-kappa B-like activity is essential for proliferation of cultured bovine vascular smooth muscle cells.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 183 citations in OpenAlex.
- Virus infection pattern imprinted and diversified the differentiation of T-cell memory in transcription and function.Frontiers in immunology · 2023Article
- Vascular smooth muscle cells in intimal hyperplasia, an update.Frontiers in physiology · 2022Review
- Lactacystin-induced kidney fibrosis: Protection by melatonin and captopril.Frontiers in pharmacology · 2022Article
- Vildagliptin Reduces Stenosis of Injured Carotid Artery in Diabetic Mouse Through Inhibiting Vascular Smooth Muscle Cell Proliferation via ER Stress/NF-κB Pathway.Frontiers in pharmacology · 2019Article
- Artificial Zinc-Finger Transcription Factor of A20 Suppresses Restenosis in Sprague Dawley Rats after Carotid Injury via the PPARα Pathway.Molecular therapy. Nucleic acids · 2017Article
- NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes.Frontiers in pharmacology · 2017Review
- Proliferation-Related Activity in Endothelial Cells Is Enhanced by Micropower Plasma.BioMed research international · 2016Article
- Smooth muscle-selective inhibition of nuclear factor-κB attenuates smooth muscle phenotypic switching and neointima formation following vascular injury.Journal of the American Heart Association · 2013Article
- NF-kB overexpression and decreased immunoexpression of AR in the muscular layer is related to structural damages and apoptosis in cimetidine-treated rat vas deferens.Reproductive biology and endocrinology : RB&E · 2013Article
- Epigenetic regulation of vascular smooth muscle cell proliferation and neointima formation by histone deacetylase inhibition.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Nuclear factor {kappa}B-mediated transactivation of telomerase prevents intimal smooth muscle cell from replicative senescence during vascular repair.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- Exploring the molecular mechanisms of OSU-03012 on vascular smooth muscle cell proliferation.Molecular and cellular biochemistry · 2010Article
- CBP knockdown inhibits angiotensin II-induced vascular smooth muscle cells proliferation through downregulating NF-kB transcriptional activity.Molecular and cellular biochemistry · 2010Article
- Development of an optimized protocol for primary culture of smooth muscle cells from rat thoracic aortas.Cytotechnology · 2009Article
- Article
- Pyrrolidine dithiocarbamate restores endothelial cell membrane integrity and attenuates monocrotaline-induced pulmonary artery hypertension.American journal of physiology. Lung cellular and molecular physiology · 2008Article
- The role of NF-kappa B and I-kappa B in intimal proliferation following balloon catheter-induced injury in the rat carotid artery.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2008Article
- Repression of B-cell linker (BLNK) and B-cell adaptor for phosphoinositide 3-kinase (BCAP) is important for lymphocyte transformation by rel proteins.Cancer research · 2008Article
- Article
- Preinterventional peak monocyte count and in-stent intimal hyperplasia after coronary stent implantation in human coronary arteries.Clinical cardiology · 2005Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have recently discovered bovine and human vascular smooth muscle cells (SMCs) express a novel constitutive Nuclear Factor-kappa B (NF-kappa B)/Rel-like activity (Lawrence, R., L.-J. Chang, U. Siebenlist, P. Bressler, and G.E. Sonenshein. 1994. J. Biol. Chem. 269:28913-28918), here termed SMC-Rel. Since cytomegalovirus (CMV) infection of human vascular SMCs has been implicated in aberrant SMC proliferation during post-angioplasty restenosis, we tested the role of NF-kappa B/Rel activity in transactivation of the CMV immediate early (ie) promoter. The basal CMV ie promoter linked to three wild-type, but not mutant, copies of its NF-kappa B element was active in bovine aortic SMCs. The anti-oxidants N-acetyl cysteine (NAC) or pentoxifylline (PTX), which are used clinically to reduce NF-kappa B/Rel activity, inhibited NF-kappa B driven promoter transactivation, and SMC-Rel binding activity. Treatment with either NAC or PTX was observed to slow the growth of the SMCs in a dose dependent fashion. Microinjection of either purified I kappa B-alpha, a naturally occurring specific inhibitor of NF-kappa B/Rel activity, or double-stranded oligonucleotides harboring wild type, but not non-binding mutants of NF-kappa B elements selectively inhibited SMC proliferation. Thus constitutive NF-kappa B/Rel activity appears essential for proliferation of vascular SMCs and might be a novel target for therapeutic intervention for restenosis.
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