ArticleThe Journal of clinical investigation1995
Tubulointerstitial injury induced in rats by a monoclonal antibody that inhibits function of a membrane inhibitor of complement.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 77 citations in OpenAlex.
- Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2.Critical care medicine · 2016Article
- C5b-9-targeted molecular MR imaging in rats with Heymann nephritis: a new approach in the evaluation of nephrotic syndrome.PloS one · 2015Article
- Tissue-specific deletion of Crry from mouse proximal tubular epithelial cells increases susceptibility to renal ischemia-reperfusion injury.Kidney international · 2014Article
- IL-22 ameliorates renal ischemia-reperfusion injury by targeting proximal tubule epithelium.Journal of the American Society of Nephrology : JASN · 2014Article
- Article
- The role of the complement system in acute kidney injury.Seminars in nephrology · 2013Review
- Complement regulation in renal disease models.Seminars in nephrology · 2013Review
- Cell cycle arrest in a model of colistin nephrotoxicity.Physiological genomics · 2013Article
- Curcumin alleviates immune-complex-mediated glomerulonephritis in factor-H-deficient mice.Immunology · 2013Article
- Endotoxemia alters tight junction gene and protein expression in the kidney.American journal of physiology. Renal physiology · 2012Article
- Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction.The American journal of pathology · 2011Article
- Dynamic control of the complement system by modulated expression of regulatory proteins.Laboratory investigation; a journal of technical methods and pathology · 2011Review
- The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Complement activation is involved in renal damage in human antineutrophil cytoplasmic autoantibody associated pauci-immune vasculitis.Journal of clinical immunology · 2009Article
- Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion.The Journal of clinical investigation · 2006Article
- Pathogenesis of Afa/Dr diffusely adhering Escherichia coli.Clinical microbiology reviews · 2005Review
- Complement regulation during pregnancy.Immunologic research · 2005Review
- Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage.The American journal of pathology · 2004Article
- The role of C5a in the development of thrombotic glomerulonephritis in rats.Clinical and experimental immunology · 2001Article
- Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
The kidney widely expresses membrane-associated complement regulatory proteins (membrane inhibitors of complement). The aim of this work was to evaluate the roles of these molecules in rat kidneys in vivo. To suppress functions of rat membrane inhibitors of complement, two mAbs, 512 and 6D1, were used. 5I2 and 6D1 inhibit functions of membrane inhibitors of complement at C3 level (rat Crry/p65) and C8/9 level (rat CD59), respectively. F(ab')2 fragment of 5I2 or 6D1 was perfused in the left kidneys, and perfusate was discarded from the renal vein. After perfusion, the left kidneys were connected to systemic circulation. In rats perfused with 5I2, mouse IgG was found in glomeruli, peritubular capillaries, vascular bundles, and tubules 15 min after recirculation. Binding of C3 and C5b-9 was evident in these areas. 1 d after perfusion with 5I2, cast formation, dilatation of tubular lumen, and tubular cell degeneration were observed. At day 4 through day 7, significant mononuclear cell infiltration and proximal tubule damage were observed. These changes were completely prevented by complement depletion. Rats perfused with 6D1 showed the binding of mouse IgG in the similar areas as 5I2, but C3 or C5b-9 deposition was not observed. Rats perfused with 6D1 or vehicle only did not show any pathology in the left kidneys. These results suggest that rat Crry/p65 plays protective roles against spontaneously occurring indiscriminate attack to tubulointerstitial tissues by autologous complement and that rat Crry/p65 is one of the important factors to maintain normal integrity of the kidney in rats.
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Registered trials
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