ArticleJournal of bacteriology1995
Mycobacterium smegmatis dnaA region and autonomous replication activity.
Article in Journal of bacteriology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Reference genome and comparative genome analysis for the WHO reference strain for Mycobacterium bovis BCG Danish, the present tuberculosis vaccine.BMC genomics · 2019Article
- Mycobacterial DNA-binding protein 1 is critical for long term survival of Mycobacterium smegmatis and simultaneously coordinates cellular functions.Scientific reports · 2017Article
- Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.PloS one · 2015Article
- Replacement of Mycobacterium smegmatis dnaA gene by Mycobacterium tuberculosis homolog results in temperature sensitivity.Tuberculosis (Edinburgh, Scotland) · 2011Article
- Mycobacterium tuberculosis origin of replication and the promoter for immunodominant secreted antigen 85B are the targets of MtrA, the essential response regulator.The Journal of biological chemistry · 2010Article
- In-vitro helix opening of M. tuberculosis oriC by DnaA occurs at precise location and is inhibited by IciA like protein.PloS one · 2009Article
- Architecture of bacterial replication initiation complexes: orisomes from four unrelated bacteria.The Biochemical journal · 2005Article
- Mycobacterium tuberculosis DnaA initiator protein: purification and DNA-binding requirements.The Biochemical journal · 2004Article
- Genomic homogeneity between Mycobacterium avium subsp. avium and Mycobacterium avium subsp. paratuberculosis belies their divergent growth rates.BMC microbiology · 2003Article
- Mutations in the CCGTTCACA DnaA box of Mycobacterium tuberculosis oriC that abolish replication of oriC plasmids are tolerated on the chromosome.Journal of bacteriology · 2002Article
- Characterization of the oriC region of Mycobacterium smegmatis.Journal of bacteriology · 1997Article
- Purification and characterization of the Streptomyces lividans initiator protein DnaA.Journal of bacteriology · 1997Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two key elements that are thought to be required for replication initiation in eubacteria are the DnaA protein, a trans-acting factor, and the replication origin, a cis-acting element. As a first step in studying the replication initiation process in mycobacteria, we have isolated a 4-kb chromosomal DNA fragment from Mycobacterium smegmatis that contains the dnaA gene. Nucleotide sequence analysis of this region revealed homologies with the rpmH gene, which codes for the ribosomal protein L34, the dnaA gene, which codes for the replication initiator protein DnaA, and the 5' end of the dnaN gene, which codes for the beta subunit of DNA polymerase III. Further, we provide evidence that when cloned into pUC18, a plasmid that is nonreplicative in M. smegmatis, the DNA fragment containing the dnaA gene and its flanking regions rendered the former capable of autonomous replication in M. smegmatis. We suggest that the M. smegmatis chromosomal origin of replication is located within the 4-kb DNA fragment.
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