Evidence map›Paper›PMID 7591157›Full record

ArticleInfection and immunity1995

Pyocyanin from Pseudomonas aeruginosa inhibits prostacyclin release from endothelial cells.

J M Kamath, B E Britigan, C D Cox, D M Shasby

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes.International journal of molecular sciences · 2017
    Review
  5. Article
  6. The multiple signaling systems regulating virulence in Pseudomonas aeruginosa.Microbiology and molecular biology reviews : MMBR · 2012
    Review
  7. Article
  8. Article
  9. Article
  10. Human targets of Pseudomonas aeruginosa pyocyanin.Proceedings of the National Academy of Sciences of the United States of America · 2003
    Article
  11. QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa.Proceedings of the National Academy of Sciences of the United States of America · 2001
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

J M KamathVeterans Administration Hospital, Iowa City, Iowa, USA.
B E Britigan
C D Cox
D M Shasby
United States Department of Veterans Affairs · US

Funding

REVERSIBLE OXIDANT INJURY TO EPITHELIUMR01HL033540 · NHLBI · UNIVERSITY OF IOWA · PI SHASBY, DOUGLAS MICHAEL · 1985 to 2005
$1.3M
MOLECULAR DETERMINANTS OF MYELOPEROXIDASE TARGETTINGP01AI028412 · NIAID · UNIVERSITY OF IOWA · PI BRITIGAN, BRADLEY E · 1989 to 1993
–
NHLBI NIH HHS HL-33540NHLBI NIH HHS HL-42275NIAID NIH HHS AI 28412
6 · The paper itself

Abstract

Pseudomonas aeruginosa pneumonia causes a vasculitis of small pulmonary arteries. While the fully developed lesion demonstrates vessel wall necrosis, the early lesion is remarkable for preservation of viable endothelium despite vessel wall invasion by bacteria. Pyocyanin, an exoproduct of P. aeruginosa, markedly inhibited prostacyclin production by pulmonary artery endothelial cells without causing cell lysis. Pyocyanin might after vascular homeostasis in the absence of cytolysis.

Indexed as

AnimalsCells, CulturedEndothelium, VascularEpoprostenolPhenolsPseudomonas aeruginosaPyocyanineSwineEpoprostenolferripyochelinPhenolsPyocyanine

Identifiers

PMID7591157
PMCPMC173706
OpenAlexW1782062856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.