ArticleInfection and immunity1995
Variation in antigenicity and infectivity of derivatives of Borrelia burgdorferi, strain B31, maintained in the natural, zoonotic cycle compared with maintenance in culture.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Deletion of a Genetic Region of lp17 Affects Plasmid Copy Number inFrontiers in cellular and infection microbiology · 2022Article
- Variations in Barbour-Stoenner-Kelly culture medium modulate infectivity and pathogenicity of Borrelia burgdorferi clinical isolates.Infection and immunity · 2004Article
- Flea-borne transmission model to evaluate vaccine efficacy against naturally acquired bubonic plague.Infection and immunity · 2004Article
- Plasmid stability during in vitro propagation of Borrelia burgdorferi assessed at a clonal level.Infection and immunity · 2003Article
- Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain background.Infection and immunity · 2002Article
- Impact of genotypic variation of Borrelia burgdorferi sensu stricto on kinetics of dissemination and severity of disease in C3H/HeJ mice.Infection and immunity · 2001Article
- Purification and characterization of Borrelia burgdorferi from feeding nymphal ticks (Ixodes scapularis).Infection and immunity · 2001Article
- Decreased infectivity in Borrelia burgdorferi strain B31 is associated with loss of linear plasmid 25 or 28-1.Infection and immunity · 2001Article
- Culture-confirmed reinfection of a person with different strains of Borrelia burgdorferi sensu stricto.Journal of clinical microbiology · 1998Article
- Culturing selects for specific genotypes of Borrelia burgdorferi in an enzootic cycle in Colorado.Journal of clinical microbiology · 1997Article
- Accelerated infectivity of tick-transmitted Lyme disease spirochetes to vector ticks.Journal of clinical microbiology · 1996Article
- Multiple infections of Ixodes scapularis ticks by Borrelia burgdorferi as revealed by single-strand conformation polymorphism analysis.Journal of clinical microbiology · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The original isolate of Borrelia burgdorferi, strain B31, can be maintained in vitro indefinitely. A number of studies have demonstrated that there are recognizable changes in the genetic composition of the spirochete after more than 60 passages. We have maintained B31 in the natural zoonotic cycle of transmission of infection between laboratory mice and laboratory-reared Ixodes ticks. To determine whether similar changes occur in the natural transmission cycle, we reisolated strain B31 from mouse skin at the fifth zoonotic cycle. This reisolated derivative had the same infectivity as the parent B31 strain, had lost the 8-kb supercoiled plasmid present in B31, and induced a gross serum antibody response indistinguishable from the B31 immune response. Analysis of antigen expression with monoclonal antibodies generated against B31, however, showed differential expression of a subset of antigens between B31 and the isolated derivative.
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