ArticleInfection and immunity1995
Myosin II is involved in capping and uroid formation in the human pathogen Entamoeba histolytica.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 76 citations in OpenAlex.
- An atypical venus fly trap domain receptor regulates motility and phagocytosis in the protozoan parasite Entamoeba histolytica.PLoS pathogens · 2026Article
- Article
- Ancestral TALE homeobox protein transcription factor regulates actin dynamics and cellular activities of protozoan parasite Entamoeba invadens.Molecular microbiology · 2024Article
- Evaluation of periodontitis parameters and plaque examination by microscopy: a report on 20 patients.Frontiers in dental medicine · 2024Article
- Live Cells Imaging and Comparative Phosphoproteomics Uncover Proteins from the Mechanobiome inInternational journal of molecular sciences · 2023Article
- Immunomodulatory effect of extracellular vesicles fromFrontiers in cellular and infection microbiology · 2022Article
- Lipids inFrontiers in cellular and infection microbiology · 2020Review
- Entamoeba histolytica under Oxidative Stress: What Countermeasure Mechanisms Are in Place?Cells · 2017Review
- Localization of phosphatidylinositol 4,5-bisphosphate to lipid rafts and uroids in the human protozoan parasite Entamoeba histolytica.Infection and immunity · 2013Article
- Differences in cap formation between invasive Entamoeba histolytica and non-invasive Entamoeba dispar.Parasitology research · 2012Article
- A proteomic and cellular analysis of uropods in the pathogen Entamoeba histolytica.PLoS neglected tropical diseases · 2011Article
- The antiretroviral lectin cyanovirin-N targets well-known and novel targets on the surface of Entamoeba histolytica trophozoites.Eukaryotic cell · 2010Article
- Downregulation of an Entamoeba histolytica rhomboid protease reveals roles in regulating parasite adhesion and phagocytosis.Eukaryotic cell · 2010Article
- A new nuclear function of the Entamoeba histolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity.PLoS pathogens · 2010Article
- Unique Asn-linked oligosaccharides of the human pathogen Entamoeba histolytica.The Journal of biological chemistry · 2008Article
- An Entamoeba histolytica rhomboid protease with atypical specificity cleaves a surface lectin involved in phagocytosis and immune evasion.Genes & development · 2008Article
- Intriguing parasites and intramembrane proteases.Genes & development · 2008Article
- Entamoeba histolytica encodes unique formins, a subset of which regulates DNA content and cell division.Infection and immunity · 2008Article
- Intestinal invasion by Entamoeba histolytica.Sub-cellular biochemistry · 2008Article
- Entamoeba histolytica expressing a dominant negative N-truncated light subunit of its gal-lectin are less virulent.Molecular biology of the cell · 2002Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The redistribution and capping of surface receptors on the human pathogen Entamoeba histolytica was observed in the presence of concanavalin A (ConA). Capping was correlated with plasma membrane folding towards the rear of the amoeba and with uroid formation. The uroid is thought to play a role in the escape of amoebae from the host immune response. To localize myosin II during capping, amoebae were incubated in the presence of ConA and then analyzed by microscopy. Myosin II was three times more concentrated within the uroid compared with the rest of the cell, suggesting that the release of caps may depend upon mechanical contraction driven by myosin II activity. The use of drugs that disrupt cytoskeletal structure or that inhibit myosin heavy chain phosphorylation demonstrated that inhibition of capping prevents uroid formation. Biochemical analysis allowed the identification of two ConA receptors which have been previously described as major pathogenic antigens of this parasite: the 96-kDa antigen, which carries alcohol dehydrogenase 2 activity and binds extracellular matrix proteins, and the Gal-GalNAc-inhibitable surface lectin, which is involved in amoeba-cell interactions and in the degradation of complement particles attached to the parasite.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.