ArticleImmunogenetics1995
Molecular characterization of rat Crry: widespread distribution of two alternative forms of Crry mRNA.
Article in Immunogenetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 40 citations in OpenAlex.
- Complement regulation in renal disease models.Seminars in nephrology · 2013Review
- C5a alters blood-brain barrier integrity in experimental lupus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Comparative functional evolution of human and mouse CR1 and CR2.Journal of immunology (Baltimore, Md. : 1950) · 2008Review
- Bacterial expression and membrane targeting of the rat complement regulator Crry: a new model anticomplement therapeutic.Protein science : a publication of the Protein Society · 2002Article
- GluR3 autoantibodies destroy neural cells in a complement-dependent manner modulated by complement regulatory proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Production and functional analysis of rat CD59 and chimeric CD59-Crry as active soluble proteins in Pichia pastoris.Immunology · 2000Article
- Article
- Inhibition of complement regulation is key to the pathogenesis of active Heymann nephritis.The Journal of experimental medicine · 1998Article
- Suppression of complement activation by recombinant Crry inhibits experimental autoimmune anterior uveitis (EAAU).Molecular immunologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The rat complement regulator 5I2 antigen/Crry is present in a widespread distribution as at least two discrete proteins of Mr 65000-70000 and 75000-85000. The molecular basis for the different proteins has not been determined. We screened a cDNA library derived from cultured rat glomerular epithelial cells with a polymerase chain reaction (PCR)-generated nucleotide probe for CR1 and Crry. Two identical clones with 1.8 kilobase inserts were obtained. Clone 6.1 consisted of 1811 nucleotides. The sequence was identical to nucleotides 42-1666 of the cDNA for rat 5I2 antigen/Crry except for 11 nucleotides at the extreme 5' and 3' ends and an exact duplication of 186 bases that would encode an additional complete short consensus repeat (SCR). By reverse transcription PCR, we show that the two forms of Crry mRNA exist in all rat cells/tissues examined. It is likely that these two Crry mRNA species differ by the absence or presence of a 186 base repeat that encodes a complete SCR. These are translated into Crry proteins, containing six and seven SCRs, respectively, which explains the different sizes of Crry proteins. The role of the SCR duplication remains to be defined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.