ArticleImmunogenetics1995
Cloning and genomic characterization of LST1: a new gene in the human TNF region.
Article in Immunogenetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Identification of potential blood biomarkers of coronary artery disease using a cuproptosis gene set.European journal of medical research · 2025Article
- Exploring Core Genes Associated with Sepsis and Systemic Inflammatory Response Syndrome Using Single-Cell Sequencing Technology.Journal of inflammation research · 2025Article
- Comprehensive multi-omics analysis of G6PC3 deficiency-related congenital neutropenia with inflammatory bowel disease.iScience · 2021Article
- Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney.Development (Cambridge, England) · 2018Article
- Lst1 deficiency has a minor impact on course and outcome of the host response to influenza A H1N1 infections in mice.Virology journal · 2016Article
- An upstream open reading frame regulates LST1 expression during monocyte differentiation.PloS one · 2014Article
- LST1/A is a myeloid leukocyte-specific transmembrane adaptor protein recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to the plasma membrane.The Journal of biological chemistry · 2012Article
- Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets.BMC genomics · 2009Article
- LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection.Immunogenetics · 2006Article
- Identification of splicing silencers and enhancers in sense Alus: a role for pseudoacceptors in splice site repression.Molecular and cellular biology · 2005Article
- Discrimination of suballeles present at the TNFd microsatellite locus using induced heteroduplex analysis.Genes and immunity · 2004Article
- The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia.Immunogenetics · 2003Article
- Complex haplotypic structure of the central MHC region flanking TNF in a West African population.Genes and immunity · 2003Article
- A physical map of the mouse H2 Bat5/Db interval.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The leucocyte specific transcript - 1 (LST1) represents the human homolog of the mouse B144 transcript, encoded within the tumor necrosis factor (TNF) region of the human major histocompatibility complex class III interval. The gene is localized about 4 kilobases upstream of the lymphotoxin beta gene. It spans a polymorphic genomic region encompassing the microsatellites TNFd and TNFe in intron 3 and a polymorphic Pvu II restriction site 260 base pairs downstream of the polyadenylation signal. Isolation of a full-length cDNA clone revealed that LST1 codes for IFN-gamma-inducible 800 nt transcripts, which are present in lymphoid tissues, T cells, macrophages, and histiocyte cell lines. The cDNA contains three long open reading frames (ORF) with the most likely ORF encoding a transmembrane protein. Its close linkage to the TNF genes and pattern of expression point toward a possible role for LST1 in the immune response.
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