ArticleGut1995
Reversible effect of phytohaemagglutinin on the growth and metabolism of rat gastrointestinal tract.
Article in Gut, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 92 citations in OpenAlex.
- The Immune-Antioxidant Trade-Off Mediated by Actinobacteria Drives Niche Differentiation: Physiological and Gut Microbiota Responses of Two Cold-Adapted Brown Frog Species to Contrasting Peak Daily Habitat Temperatures.Animals : an open access journal from MDPI · 2025Article
- Prospects for developing allergen-depleted food crops.The plant genome · 2023Review
- Ethanolic extract of okra has a potential gastroprotective effect on acute gastric lesions in Sprague Dawley rats.Food science & nutrition · 2020Article
- Tepary bean (Toxicology research · 2020Article
- Dietary Lectin exclusion: The next big food trend?World journal of gastroenterology · 2019Review
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- Egg perivitelline fluid of the invasive snailPeerJ · 2018Article
- A lectin of a non-invasive apple snail as an egg defense against predation alters the rat gut morphophysiology.PloS one · 2018Article
- Scientific Opinion on an application by Dow AgroSciences LLC (EFSA-GMO-NL-2011-91) for the placing on the market of genetically modified herbicide-tolerant soybean DAS-68416-4 for food and feed uses, import and processing under Regulation (EC) No 1829/2003.EFSA journal. European Food Safety Authority · 2017Article
- Scientific opinion on an application by Dow AgroSciences LLC (EFSA-GMO-NL-2012-106) for the placing on the market of genetically modified herbicide-tolerant soybean DAS-44406-6 for food and feed uses, import and processing under Regulation (EC) No 1829/2003.EFSA journal. European Food Safety Authority · 2017Article
- A Glucosamine-Specific Lectin from Green Dragon No. 8 Beans (Phaseolus vulgaris) Induced Apoptosis on Nasopharyngeal Carcinoma Cells.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Insights into embryo defenses of the invasive apple snail Pomacea canaliculata: egg mass ingestion affects rat intestine morphology and growth.PLoS neglected tropical diseases · 2014Article
- A review on botanical species and chemical compounds with appetite suppressing properties for body weight control.Plant foods for human nutrition (Dordrecht, Netherlands) · 2013Review
- Potential efficacy of preparations derived from Phaseolus vulgaris in the control of appetite, energy intake, and carbohydrate metabolism.Diabetes, metabolic syndrome and obesity : targets and therapy · 2009Article
- Evolutionary analysis of the APA genes in the Phaseolus genus: wild and cultivated bean species as sources of lectin-related resistance factors?TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2007Article
- Low-dose intragastric administration of Phaseolus vulgaris agglutinin (PHA) does not induce immunoglobulin E (IgE) production in Sprague-Dawley rats.Glycoconjugate journal · 2001Article
- Decreased levels of heat shock proteins in gut epithelial cells after exposure to plant lectins.Gut · 2000Article
- Binding of FITC-labelled lectins to the gastrointestinal epithelium of the rat.Pathology oncology research : POR · 2000Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lectin, phytohaemagglutinin, present in beans survives passage through the gastrointestinal tract in a biologically and immunologically intact form. It is known that by binding to the brush border membranes of the small intestine phytohaemagglutinin induces its hyperplastic growth. However, its effect on the other parts of the gut are not known. This study considered the dose and time dependent changes in the gastrointestinal tract exposed to phytohaemagglutinin. Lectin binding was detected by polyclonal antibodies using PAP staining to the surface and the parietal cell region of the stomach, the brush border epithelium of the small intestine and to the surface membrane of the caecum and colon. To characterise the metabolic changes in the gut organ weights, protein, RNA, DNA, and polyamine contents were measured. While phytohaemagglutinin induced a dose and time dependent growth of the small intestine by lengthening the tissue and thickening the gut wall by increasing the number of crypt cells, the lectin also changed the size and metabolism of the large intestine and pancreas, but this growth was by hypertrophy. Phytohaemagglutinin in the diet influences the size, metabolism, and function of the entire digestive tract. The lectin induced changes were fully or partially reversed within three days.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.