ArticleDiabetologia1995
Increased hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in NIDDM.
Article in Diabetologia, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 122 citations in OpenAlex.
- Trial
- Effect of hormone replacement therapy on plasma lipoprotein levels and coronary atherosclerosis progression in postmenopausal women according to type 2 diabetes mellitus status.Metabolism: clinical and experimental · 2010Trial
- Influence of simvastatin on apoB-100 secretion in non-obese subjects with mild hypercholesterolemia.Lipids · 2010Trial
- Effects of 20 mg rosuvastatin on VLDL1-, VLDL2-, IDL- and LDL-ApoB kinetics in type 2 diabetes.Diabetologia · 2008 · on this mapTrial
- Effect of exercise on postprandial lipemia in men with hypertriglyceridemia.European journal of applied physiology · 2006Trial
- Genetically modified mouse models to study hepatic neutral lipid mobilization.Biochimica et biophysica acta. Molecular basis of disease · 2019Review
- Lysosomal acid lipase deficiency - early diagnosis is the key.Hepatic medicine : evidence and research · 2019Review
- Article
- Coronary Heart Disease in Postmenopausal Women with Type II Diabetes Mellitus and the Impact of Estrogen Replacement Therapy: A Narrative Review.International journal of endocrinology · 2014Review
- Evaluation of buspirone on streptozotocin induced type 1 diabetes and its associated complications.BioMed research international · 2014Article
- Immune mechanisms in atherosclerosis, especially in diabetes type 2.Frontiers in endocrinology · 2013Review
- The regulation of ApoB metabolism by insulin.Trends in endocrinology and metabolism: TEM · 2013Review
- Hormone replacement therapy and physical function in healthy older men. Time to talk hormones?Endocrine reviews · 2012Review
- The distinctive nature of atherosclerotic vascular disease in diabetes: pathophysiological and morphological insights.Current diabetes reports · 2012Review
- Fish oil -- how does it reduce plasma triglycerides?Biochimica et biophysica acta · 2012Article
- Polymorphic variations in manganese superoxide dismutase (MnSOD), glutathione peroxidase-1 (GPX1), and catalase (CAT) contribute to elevated plasma triglyceride levels in Chinese patients with type 2 diabetes or diabetic cardiovascular disease.Molecular and cellular biochemistry · 2012Article
- Article
- FoxO1 integrates insulin signaling to VLDL production.Cell cycle (Georgetown, Tex.) · 2008Review
- Effects of the PPARgamma agonist pioglitazone on lipoprotein metabolism in patients with type 2 diabetes mellitus.The Journal of clinical investigation · 2005Article
- Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease.The Journal of clinical investigation · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We measured the hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 (VLDL apoB) using a stable isotope gas-chromatography mass-spectrometry method in six patients with non-insulin-dependent diabetes mellitus (NIDDM) (four males, two females, age 57.5 +/- 2.2 years (mean +/- SEM), weight 88.2 +/- 5.5 kg, glycated haemoglobin (HbA1) 8.5 +/- 0.5%, plasma total cholesterol concentration 5.7 +/- 0.5 mmol/l, triglyceride 3.8 +/- 0.9 mmol/l, high-density lipoprotein (HDL) cholesterol 1.0 +/- 0.1 mmol/l) and six non-diabetic subjects matched for age, sex and weight (four males, two females, age 55.7 +/- 2.8 years, weight 85.8 +/- 5.6 kg, HbA1 6.5 +/- 0.1%, plasma total cholesterol concentration 5.7 +/- 0.5 mmol/l, triglyceride 1.2 +/- 0.1 mmol/l, HDL cholesterol 1.4 +/- 0.1 mmol/l). HbA1, plasma triglyceride and mevalonic acid (an index of cholesterol synthesis in vivo) concentrations were significantly higher in the diabetic patients than in the non-diabetic subjects (p = 0.006, p = 0.02 and p = 0.004, respectively). VLDL apoB absolute secretion rate was significantly higher in the diabetic patients compared with the non-diabetic subjects (2297 +/- 491 vs 921 +/- 115 mg/day, p < 0.05), but there was no significant difference in the fractional catabolic rate of VLDL apoB. There was a positive correlation between VLDL apoB secretion rate and (i) fasting C-peptide (r = 0.84, p = 0.04) and (ii) mevalonic acid concentration (r = 0.83, p < 0.05) in the diabetic patients but not in the non-diabetic subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.