ArticleThe EMBO journal1995
Thymic abnormalities and enhanced apoptosis of thymocytes and bone marrow cells in transgenic mice overexpressing Cu/Zn-superoxide dismutase: implications for Down syndrome.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 127 citations in OpenAlex.
- Review
- The aetiology of atypical bone health in individuals with Down syndrome.Archives of osteoporosis · 2023Review
- Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications.Physiological reviews · 2016Review
- Trx1/TrxR1 system regulates post-selected DP thymocytes survival by modulating ASK1-JNK/p38 MAPK activities.Immunology and cell biology · 2015Article
- Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome.BMC medical genomics · 2013Article
- PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction.International journal of nanomedicine · 2012Article
- Loss of Dicer in Sertoli cells has a major impact on the testicular proteome of mice.Molecular & cellular proteomics : MCP · 2011Article
- Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge.Free radical biology & medicine · 2011Article
- Enhanced susceptibility of T lymphocytes to oxidative stress in the absence of the cellular prion protein.Cellular and molecular life sciences : CMLS · 2011Article
- Intrinsic defect of the immune system in children with Down syndrome: a review.Clinical and experimental immunology · 2009Review
- Faithful tissue-specific expression of the human chromosome 21-linked COL6A1 gene in BAC-transgenic mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor.Dose-response : a publication of International Hormesis Society · 2006Article
- Hydrogen peroxide as a diffusible signal molecule in synaptic plasticity.Molecular neurobiology · 2004Review
- Paradoxical actions of hydrogen peroxide on long-term potentiation in transgenic superoxide dismutase-1 mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice.The EMBO journal · 2001Article
- Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Nitric oxide protects PC12 cells from serum deprivation-induced apoptosis by cGMP-dependent inhibition of caspase signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- The nature of antioxidant defense mechanisms: a lesson from transgenic studies.Environmental health perspectives · 1998Review
- Altered Ca2+ signaling and mitochondrial deficiencies in hippocampal neurons of trisomy 16 mice: a model of Down's syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Mitochondrial proliferation and paradoxical membrane depolarization during terminal differentiation and apoptosis in a human colon carcinoma cell line.The Journal of cell biology · 1997Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The copper-zinc superoxide dismutase (CuZnSOD) gene resides on chromosome 21 and is overexpressed in Down syndrome (DS) patients. Transgenic CuZnSOD mice with elevated levels of CuZnSOD were used to determine whether, as in DS, overexpression of CuZnSOD was also associated with thymus and bone marrow abnormalities. Three independently derived transgenic CuZnSOD strains had abnormal thymi showing diminution of the cortex and loss of corticomedullary demarcation, resembling thymic defects in children with DS. Transgenic CuZnSOD mice were also more sensitive than control mice to in vivo injection of lipopolysaccharide (LPS), reflected by an earlier onset and enhanced apoptotic cell death in the thymus. This higher susceptibility to LPS-induced apoptosis was associated with an increased production of hydrogen peroxide and a higher degree of lipid peroxidation. When cultured under suboptimal concentrations of interleukin 3 or in the presence of tumour necrosis factor, bone marrow cells from transgenic CuZnSOD mice produced 2- to 3-fold less granulocyte and macrophage colonies than control. The results indicate that transgenic CuZnSOD mice have certain thymus and bone marrow abnormalities which are similar to those found in DS patients, and that the defects are presumably due to an increased oxidative damage resulting in enhanced cell death by apoptosis.
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