ArticleClinical and experimental immunology1995
Immunological markers indicating the effectiveness of pharmacological treatment in human hydatid disease.
Article in Clinical and experimental immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 122 citations in OpenAlex.
- Long-term serological evaluation of patients with cystic echinococcosis treated with benzimidazole carbamates.Clinical and experimental immunology · 2002Trial
- Characterization of protein cargo of Echinococcus granulosus extracellular vesicles in drug response and its influence on immune response.Parasites & vectors · 2023Article
- Eugenol Essential Oil and Nanoemulsion as Antihydatic Agents with Antifibrotic and Immunomodulatory Effects in Cystic Echinococcosis.Tropical medicine and infectious disease · 2023Article
- Perineal and right femoral hydatid cyst in a female with regional paresthesia: a rare case report.BMC surgery · 2022Article
- Membrane Technology for Rapid Point-of-Care Diagnostics for Parasitic Neglected Tropical Diseases.Clinical microbiology reviews · 2021Article
- The effects ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- Fasciola hepatica coinfection modifies the morphological and immunological features of Echinococcus granulosus cysts in cattle.Veterinary research · 2020Article
- Guide to Immunopharmacology: a database to boost immunology education, research and therapy.Immunology · 2020Article
- Evaluation of the therapeutic efficacy of albendazole-loaded silver nanoparticles againstJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2019Article
- Pathological fracture of femoral neck in a middle-aged woman: a rare presentation of primary hydatid cyst disease in humans.BMJ case reports · 2018Article
- IL-4 gene expression in adventitial layer (fibrous layer) of hepatic ovine and bovine hydatid cysts.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2016Article
- Polyfunctional Specific Response to Echinococcus Granulosus Associates to the Biological Activity of the Cysts.PLoS neglected tropical diseases · 2015Article
- Lateral flow test using Echinococcus granulosus native antigen B and comparison of IgG and IgG4 dipsticks for detection of human cystic echinococcosis.The American journal of tropical medicine and hygiene · 2014Article
- Distinctive cytokine, chemokine, and antibody responses in Echinococcus multilocularis-infected patients with cured, stable, or progressive disease.Medical microbiology and immunology · 2014Article
- Cystic echinococcosis of the liver: A primer for hepatologists.World journal of hepatology · 2014Review
- Induction of protective T-helper 1 immune responses against Echinococcus granulosus in mice by a multi-T-cell epitope antigen based on five proteins.Memorias do Instituto Oswaldo Cruz · 2013Article
- IgG4 detection of Echinococcus granulosus paramyosin is a useful diagnostic test for human hydatidosis.Clinical and vaccine immunology : CVI · 2013Article
- Comparative study of nitric oxide (NO) production during human hydatidosis: relationship with cystic fluid fertility.Parasitology research · 2013Article
- Antitumor activity of human hydatid cyst fluid in a murine model of colon cancer.TheScientificWorldJournal · 2013Article
- The study of apoptotic bifunctional effects in relationship between host and parasite in cystic echinococcosis: a new approach to suppression and survival of hydatid cyst.Parasitology research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relation of interferon-gamma (IFN-gamma), IL-4, IL-10 production and specific IgE, total IgG, IgG subclass expression to the effectiveness of pharmacological treatment in human hydatid disease (Echinococcus granulosus infection) was evaluated in 27 hydatid patients divided into four clinical groups according to their response to albendazole/mebendazole therapy (full, partial, low and non-responders). After parasite antigen stimulation, peripheral blood mononuclear cells (PBMC) from full responders produced significantly more IFN-gamma (P = 0.038), significantly less IL-4 (P = 0.001) and less IL-10 than PBMC from non-responders. PBMC from partial and low responders produced intermediate cytokine concentrations. ELISA determining immunoglobulin production showed that sera from all non-responders had IgE and IgG4 antibodies, both regulated by IL-4. In contrast to IgG4, IgE decreased rapidly in full responders. Full responders also showed the highest percentage of IgG3 reactions. Qualitative analysis of total IgG responses in hydatid patients' sera determined by immunoblotting showed that binding profiles to hydatid cyst fluid antigen differed in the four groups of treated patients. Non-responders had the highest percentage of reactions to all subunits of antigens 5 and B, and full responders had the highest percentage of reactions to antigen 5 alone. The high IFN-gamma production associated with a lack of IL-4 and low IL-10 production in the full responders, and vice versa the high IL-4 and IL-10 production associated with lack of or low IFN-gamma production in the non-responders implies Th1 cell activation in protective immunity and Th2 cell activation in susceptibility to hydatid disease. IgE may be a useful marker of therapeutic success in hydatid patients with pretreatment specific IgE antibodies. IgG subclass responses and differential immunoglobulin subclass binding pattern to hydatid antigens may also be useful in the immunosurveillance of hydatid disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.