Evidence map›Paper›PMID 7585121›Full record

ArticleNature medicine1995

Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate.

C Duncan, H Dougall, P Johnston, S Green, R Brogan, C Leifert, L Smith, M Golden, N Benjamin

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Nature medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01384968 (Acute Dietary Nitrate Supplementation to Improve Performance in Endurance Trained Athletes), which is not on this map. Cited by 206 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
206citing papers in PubMed, 11 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01384968 nacompletednot on this mapstarted 2011, after this paper: background citation

Acute Dietary Nitrate Supplementation to Improve Performance in Endurance Trained Athletes

TypeinterventionalSponsorMaastricht University Medical CenterRan2011 to 2012Enrolled20ConditionsAcute Nitrate Ingestion on Athletic PerformanceArmsbeetroot juice
3 · Its place in the literature

Who cites it

206 citing papers in PubMed, 11 syntheses or guidelines pooled it, 733 citations in OpenAlex.

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  17. Dietary nitrate supplementation effect on dynamic cerebral autoregulation in normoxia and acute hypoxia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
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146 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

C DuncanDepartment of Medicine and Therapeutics, University of Aberdeen Medical School, Foresterhill, UK.
H Dougall
P Johnston
S Green
R Brogan
C Leifert
L Smith
M Golden
N Benjamin
University of Aberdeen · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High concentrations of nitrite present in saliva (derived from dietary nitrate) may, upon acidification, generate nitrogen oxides in the stomach in sufficient amounts to provide protection from swallowed pathogens. We now show that, in the rat, reduction of nitrate to nitrite is confined to a specialized area on the posterior surface of the tongue, which is heavily colonized by bacteria, and that nitrate reduction is absent in germ-free rats. We also show that in humans increased salivary nitrite production resulting from nitrate intake enhances oral nitric oxide production. We propose that the salivary generation of nitrite is accomplished by a symbiotic relationship involving nitrate-reducing bacteria on the tongue surface, which is designed to provide host defence against microbial pathogens in the mouth and lower gut. These results provide further evidence for beneficial effects of dietary nitrate.

Indexed as

DietAdultAnimalsBacteria, AnaerobicBacterial ProteinsBiotransformationFood MicrobiologyGastric MucosaGastrointestinal ContentsGerm-Free LifeHumansHydrogen-Ion ConcentrationMaleMouthwashesNitrate ReductaseNitrate ReductasesBacterial ProteinsMouthwashesNitrate ReductaseNitrate ReductasesNitratesNitric OxideNitritesNitrosamines

Identifiers

PMID7585121
OpenAlexW2071755029

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.