ArticleNature medicine1995
Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres.
Article in Nature medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- Cell Therapy for Stroke: A Mechanistic Analysis.Neurosurgery · 2021Review
- Xenogeneic and Stem Cell-Based Therapy for Cardiovascular Diseases: Genetic Engineering of Porcine Cells and Their Applications in Heart Regeneration.International journal of molecular sciences · 2020Review
- Glial cells in intracerebral transplantation for Parkinson's disease.Neural regeneration research · 2020Review
- Neuronal Replacement as a Tool for Basal Ganglia Circuitry Repair: 40 Years in Perspective.Frontiers in cellular neuroscience · 2020Review
- hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson's Disease.Cell reports · 2019Article
- Toward Functional Restoration of the Central Nervous System: A Review of Translational Neuroscience Principles.Neurosurgery · 2019Review
- Target-specific forebrain projections and appropriate synaptic inputs of hESC-derived dopamine neurons grafted to the midbrain of parkinsonian rats.The Journal of comparative neurology · 2018Article
- Astrogliosis has Different Dynamics after Cell Transplantation and Mechanical Impact in the Rodent Model of Parkinson's Disease.Balkan medical journal · 2018Article
- A PITX3-EGFP Reporter Line Reveals Connectivity of Dopamine and Non-dopamine Neuronal Subtypes in Grafts Generated from Human Embryonic Stem Cells.Stem cell reports · 2017Article
- Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments.Translational neurodegeneration · 2017Review
- Mechanochemical regulation of growth cone motility.Frontiers in cellular neuroscience · 2015Review
- Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease.Cell stem cell · 2014Article
- Human neural stem cells survive long term in the midbrain of dopamine-depleted monkeys after GDNF overexpression and project neurites toward an appropriate target.Stem cells translational medicine · 2014Article
- Melatonin-based therapeutics for neuroprotection in stroke.International journal of molecular sciences · 2013Review
- Neural progenitors derived from human induced pluripotent stem cells survive and differentiate upon transplantation into a rat model of amyotrophic lateral sclerosis.Stem cells translational medicine · 2013Article
- The immunological challenges of cell transplantation for the treatment of Parkinson's disease.Brain research bulletin · 2012Review
- Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation.Frontiers in cellular neuroscience · 2012Article
- Neural stem/progenitor cells as a promising candidate for regenerative therapy of the central nervous system.Frontiers in cellular neuroscience · 2012Article
- Cellular therapy and induced neuronal replacement for Huntington's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2011Review
- Stem cell technology for neurodegenerative diseases.Annals of neurology · 2011Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Clinical trials are under way using fetal cells to repair damaged neuronal circuitry. However, little is known about how transplanted immature neurons can grow anatomically correct connections in the adult central nervous system (CNS). We transplanted embryonic porcine neural cells in vivo into adult rat brains with neuronal and axonal loss typical of Parkinson's or Huntington's disease. Using complementary species-specific cellular markers, we found donor axons and CD44+ astroglial fibres in host white matter tracts up to 8 mm from CNS transplant sites, although only donor axons were capable of reaching correct gray matter target regions. This work demonstrates that adult host brain can orient growth of transplanted neurons and that there are differences in transplant donor glial and axonal growth patterns in cellular repair of the mature CNS.
Indexed as
Identifiers
7584993What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.