Evidence map›Paper›PMID 7582501›Full record

ArticleBritish journal of pharmacology1995

Glucocorticoid-induced annexin 1 secretion by monocytes and peritoneal leukocytes.

C Coméra, F Russo-Marie

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 65 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

C ComéraINSERM U332, Institut Cochin de Génétique Moléculaire, Paris, France.
F Russo-Marie
Institut Cochin · FRPharmacochimie et Pharmacologie pour le Développement · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1. We have studied the ability of the glucocorticoid, dexamethasone, to induce annexin 1 secretion by either human blood monocytes or rat peritoneal leukocytes. 2. The in vivo treatment of rats with dexamethasone (1.25 mg kg-1) selectively induced secretion of annexin 1 by peritoneal leukocytes, as assessed by incubating these cells in culture medium. Annexin 1 secretion was also induced in human cultured monocytes, in vitro, by 10(-6) M dexamethasone. 3. Annexin 1 secretion was inhibited in the presence of 20 mM NH4Cl or by conducting the experiments at 18 degrees C. In contrast, it was not inhibited by monensin, nocodazole or brefeldin A. 4. The time necessary for annexin 1 synthesis and secretion was less than 15 min. 5. These data indicate that glucocorticoids induce annexin 1 secretion by monocytes or peritoneal leukocytes. Because it is not inhibited by monensin, nocodazole or brefeldin A and it is rapid, annexin 1 secretion seems to occur by the secretory pathway similar to that used by several cytosolic proteins such as interleukin-1 beta.

Indexed as

AnimalsAnnexin A1Blotting, WesternCells, CulturedDexamethasoneGlucocorticoidsHumansLeukocytesMaleMonocytesRatsRats, WistarAnnexin A1DexamethasoneGlucocorticoids

Identifiers

PMID7582501
PMCPMC1909025
OpenAlexW1996263138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.