ArticleBritish journal of pharmacology1995
The involvement of ATP-sensitive potassium channels in beta-adrenoceptor-mediated vasorelaxation in the rat isolated mesenteric arterial bed.
Article in British journal of pharmacology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 69 citations in OpenAlex.
- Investigating the Role of G Protein βγ in Kv7-Dependent Relaxations of the Rat Vasculature.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- ATP-sensitive potassium channels modulate in vitro tocolytic effects of β₂-adrenergic receptor agonists on uterine muscle rings in rats in early but not in late pregnancy.Croatian medical journal · 2015Article
- Vasodilatory mechanisms of beta receptor blockade.Current hypertension reports · 2012Review
- Impaired β-adrenoceptor-induced relaxation in small mesenteric arteries from DOCA-salt hypertensive rats is due to reduced K(Ca) channel activity.Pharmacological research · 2012Article
- Vascular hyperpolarization to β-adrenoceptor agonists evokes spreading dilatation in rat isolated mesenteric arteries.British journal of pharmacology · 2011Article
- Principal role of adenylyl cyclase 6 in K⁺ channel regulation and vasodilator signalling in vascular smooth muscle cells.Cardiovascular research · 2011Article
- Effect of inhibition of extracellular signal-regulated kinase on relaxations to beta-adrenoceptor agonists in porcine isolated blood vessels.British journal of pharmacology · 2009Article
- PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by beta-adrenergic receptors.American journal of physiology. Regulatory, integrative and comparative physiology · 2007Article
- Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells.Journal of anesthesia · 2007Review
- Changes in the vascular beta-adrenoceptor-activated signalling pathway in 2Kidney-1Clip hypertensive rats.British journal of pharmacology · 2004Article
- Contribution of Na+ -Ca2+ exchanger to pinacidil-induced relaxation in the rat mesenteric artery.British journal of pharmacology · 2003Article
- Involvement of both G protein alphas and beta gamma subunits in beta-adrenergic stimulation of vascular L-type Ca(2+) channels.British journal of pharmacology · 2001Article
- Possible mechanisms underlying the vasodilatation induced by olprinone, a phosphodiesterase III inhibitor, in rabbit coronary artery.British journal of pharmacology · 2000Article
- Role of potassium channels and nitric oxide in the relaxant effects elicited by beta-adrenoceptor agonists on hypoxic vasoconstriction in the isolated perfused lung of the rat.British journal of pharmacology · 1999Article
- Potentiation of cyclic AMP-mediated vasorelaxation by phenylephrine in pulmonary arteries of the rat.British journal of pharmacology · 1999Article
- ATP-sensitive K+ channel activation by calcitonin gene-related peptide and protein kinase A in pig coronary arterial smooth muscle.The Journal of physiology · 1998Article
- ATP-sensitive potassium channels mediate contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle.The Journal of clinical investigation · 1997Article
- Modulation of vasorelaxant responses to potassium channel openers by basal nitric oxide in the rat isolated superior mesenteric arterial bed.British journal of pharmacology · 1996Article
- Effects of glibenclamide on the regional haemodynamic actions of alpha-trinositol and its influence on responses to vasodilators in conscious rats.British journal of pharmacology · 1996Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. We have used the isolated buffer-perfused superior mesenteric arterial bed of the rat to assess the involvement of ATP-sensitive potassium (KATP) channels in the vasorelaxant responses to beta-adrenoceptor agonists. 2. The vasorelaxant potencies of the non-selective beta-adrenoceptor agonist, isoprenaline, the beta 1-adrenoceptor agonist, dobutamine and the beta 2-adrenoceptor agonist, terbutaline were all significantly (P < 0.05) reduced (isoprenaline, ED50 = 265 +/- 31 pmol v. 1.05 +/- 0.42 nmol; dobutamine, ED50 = 294 +/- 67 pmol v. 497 +/- 115 pmol; terbutaline, ED50 = 157 +/- 26 nmol v. 452 +/- 120 nmol) in the presence of the KATP-channel blocker, glibenclamide. 3. The presence of glibenclamide only weakly influenced the vasorelaxant properties of salbutamol, a beta 2-adrenoceptor agonist, while those of verapamil, a beta-adrenoceptor-independent vasorelaxant, were unaffected. 4. In radioligand binding experiments, glibenclamide (1 nM-100 microM) did not displace any specific [3H]-dihydroalprenolol binding from rat beta-adrenoceptors. Therefore, glibenclamide does not bind to beta-adrenoceptors at the concentration used in the present investigation. 5. Vasorelaxant responses to dibutyryl cyclic AMP, the cell permeable analogue of cyclic AMP, were also unaffected by glibenclamide, indicating that the coupling of beta-adrenoceptors to KATP-channels occurs independently of the elevation of intracellular cyclic AMP. 6. We have shown that a significant element of the vasorelaxant responses to both beta 1- and beta 2-adrenoceptor activation involves the opening of KATP-channels. In conclusion, KATP-channels may play a physiological role in beta-adrenoceptor-mediated vasodilatation.
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