ArticleMolecular biology of the cell1995
Domains required for CENP-C assembly at the kinetochore.
Article in Molecular biology of the cell, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Molecular basis of CENP-C association with the CENP-A nucleosome at yeast centromeres.Genes & development · 2017Article
- Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition.Nature communications · 2017Article
- A Molecular View of Kinetochore Assembly and Function.Biology · 2017Review
- Targeting of Arabidopsis KNL2 to Centromeres Depends on the Conserved CENPC-k Motif in Its C Terminus.The Plant cell · 2017Article
- Differential Binding Partners of the Mis18α/β YIPPEE Domains Regulate Mis18 Complex Recruitment to Centromeres.Cell reports · 2016Article
- The dimerization domain of PfCENP-C is required for its functions as a centromere protein in human malaria parasite Plasmodium falciparum.Malaria journal · 2014Article
- Overlapping kinetochore targets of CK2 and Aurora B kinases in mitotic regulation.Molecular biology of the cell · 2011Article
- Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.Current biology : CB · 2011Article
- Adaptive evolution of foundation kinetochore proteins in primates.Molecular biology and evolution · 2010Article
- Dual recognition of CENP-A nucleosomes is required for centromere assembly.The Journal of cell biology · 2010Article
- Dissection of CENP-C-directed centromere and kinetochore assembly.Molecular biology of the cell · 2009Article
- Structural and functional dissection of Mif2p, a conserved DNA-binding kinetochore protein.Molecular biology of the cell · 2008Article
- Genetic interactions of separase regulatory subunits reveal the diverged Drosophila Cenp-C homolog.Genes & development · 2005Article
- Adaptive evolution of centromere proteins in plants and animals.Journal of biology · 2004Article
- CENP-H, a constitutive centromere component, is required for centromere targeting of CENP-C in vertebrate cells.The EMBO journal · 2001Article
- Structural requirements and dynamics of mitosin-kinetochore interaction in M phase.Molecular and cellular biology · 1999Article
- Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites.The Journal of cell biology · 1997Article
- Fission yeast mal2+ is required for chromosome segregation.Molecular and cellular biology · 1996Article
- Analysis of extrachromosomal structures containing human centromeric alphoid satellite DNA sequences in mouse cells.Chromosoma · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Chromosomes segregate at mitosis along microtubules attached to the kinetochore, an organelle that assembles at the centromere. Despite major advances in defining molecular components of the yeast segregation apparatus, including discrete centromere sequences and proteins of the kinetochore, relatively little is known of corresponding elements in more complex eukaryotes. We show here that human CENP-C, a human autoantigen previously localized to the kinetochore, assembles at centromeres of divergent species, and that the specificity of this targeting is maintained by an inherent destruction mechanism that prevents the accumulation of CENP-C and toxicity of mistargeted CENP-C. The N-terminus of CENP-C is not only required for CENP-C destruction but renders unstable proteins that otherwise possess long half-lives. The conserved targeting of CENP-C is underscored by the discovery of significant homology between regions of CENP-C and Mif2, a protein of Saccharomyces cerevisiae required for the correct segregation of chromosomes. Mutations in the Mif2 homology domain of CENP-C impair the ability of CENP-C to assemble at the kinetochore. Together, these data indicate that essential elements of the chromosome segregation apparatus are conserved in eukaryotes.
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Registered trials
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