ArticleMolecular biology of the cell1995
Interspecies conservation of outer arm dynein intermediate chain sequences defines two intermediate chain subclasses.
Article in Molecular biology of the cell, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- Structure and function of outer dynein arm intermediate and light chain complex.Molecular biology of the cell · 2016Article
- Article
- Regulatory ATPase sites of cytoplasmic dynein affect processivity and force generation.The Journal of biological chemistry · 2008Article
- Dyneins across eukaryotes: a comparative genomic analysis.Traffic (Copenhagen, Denmark) · 2007Article
- Three-dimensional structures of the flagellar dynein-microtubule complex by cryoelectron microscopy.The Journal of cell biology · 2007Article
- IC138 is a WD-repeat dynein intermediate chain required for light chain assembly and regulation of flagellar bending.Molecular biology of the cell · 2004Article
- The human dynein intermediate chain 2 gene (DNAI2): cloning, mapping, expression pattern, and evaluation as a candidate for primary ciliary dyskinesia.Human genetics · 2000Article
- A molecular genetic analysis of the interaction between the cytoplasmic dynein intermediate chain and the glued (dynactin) complex.Molecular biology of the cell · 2000Article
- Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia.American journal of human genetics · 1999Article
- The Chlamydomonas IDA7 locus encodes a 140-kDa dynein intermediate chain required to assemble the I1 inner arm complex.Molecular biology of the cell · 1998Article
- The Mr 140,000 intermediate chain of Chlamydomonas flagellar inner arm dynein is a WD-repeat protein implicated in dynein arm anchoring.Molecular biology of the cell · 1998Article
- Identification of the t complex-encoded cytoplasmic dynein light chain tctex1 in inner arm I1 supports the involvement of flagellar dyneins in meiotic drive.The Journal of cell biology · 1998Article
- Is outer arm dynein intermediate chain 1 multifunctional?Molecular biology of the cell · 1996Article
- Identification and developmental regulation of a neuron-specific subunit of cytoplasmic dynein.Molecular biology of the cell · 1996Article
- The 78,000-M(r) intermediate chain of Chlamydomonas outer arm dynein is a microtubule-binding protein.The Journal of cell biology · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunological analysis showed that antibodies against the intermediate chains (ICs) IC2 and IC3 of sea urchin outer arm dynein specifically cross-reacted with intermediate chains IC78 and IC69, respectively, of Chlamydomonas outer arm dynein. In contrast, no specific cross-reactivity with any Chlamydomonas outer arm polypeptide was observed using antibody against IC1 of sea urchin outer arm dynein. To learn more about the relationships between the different ICs, overlapping cDNAs encoding all of IC2 and IC3 of sea urchin were isolated and sequenced. Comparison of these sequences with those previously obtained for the Chlamydomonas ICs revealed that, although all four chains are homologous, sea urchin IC2 is much more closely related to Chlamydomonas IC78 (45.8% identity), and sea urchin IC3 is much more closely related to Chlamydomonas IC69 (48.5% identity), than either sea urchin chain is related to the other (23.5% identity). For homologous pairs, the similarities extend throughout the full lengths of the chains. Regions of similarity between all four ICs and the IC (IC74) of cytoplasmic dynein, located in the C-terminal halves of the chains, are due primarily to conservation of the WD repeats present in all of these ICs. This is the first demonstration that structural differences between individual ICs within an outer arm dynein have been highly conserved in the dyneins of distantly related species. The results provide a basis for the subclassification of these chains.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.