ArticleBritish journal of cancer1995
Molecular and immunohistochemical analysis of P53 in phaeochromocytoma.
Article in British journal of cancer, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 31 citations in OpenAlex.
- Malignant paraganglioma of the urinary bladder: Immunohistochemical study of prognostic indicators.Endocrine pathology · 2005Article
- Molecular genetic alterations in adrenal and extra-adrenal pheochromocytomas and paragangliomas.Endocrine pathology · 2003Review
- The clinicopathological features and importance of p53, Rb, and mdm2 expression in phaeochromocytomas and paragangliomas.Journal of clinical pathology · 2001Article
- p53 protein and its messenger ribonucleic acid in human adrenal tumors.Journal of endocrinological investigation · 1998Article
- Bcl-2 and c-Myc, but not bax and p53, are expressed during human medullary thyroid tumorigenesis.The American journal of pathology · 1998Article
- Concurrent Pheochromocytoma, Paraganglioma, Papillary Thyroid Carcinoma, and Desmoid Tumor: A Case Report with Analyses at the Molecular Level.Endocrine pathology · 1998Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We searched for mutations of the p53 gene in 25 phaeochromocytomas using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis of the entire conserved region of the gene, encompassing exons 4-8; expression of the p53 protein was assessed by immunohistochemistry. No mutations were found, while a polymorphism in codon 72 was observed. Immunohistochemistry revealed nuclear p53 overexpression in one tumour sample. We conclude that mutations of the 'hotspot' region of the p53 gene do not seem to play a role in the pathogenesis of phaeochromocytoma.
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Registered trials
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