ArticleThe Biochemical journal1995
Molecular cloning of mouse intestinal trefoil factor and its expression during goblet cell changes.
Article in The Biochemical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier.Scientific reports · 2015Article
- Trefoil Factor 3 (TFF3) Is Regulated by Food Intake, Improves Glucose Tolerance and Induces Mucinous Metaplasia.PloS one · 2015Article
- Trefoil factor family peptide 2 acts pro-proliferative and pro-apoptotic in the murine retina.Histochemistry and cell biology · 2011Article
- The discovery of the microphthalmia locus and its gene, Mitf.Pigment cell & melanoma research · 2010Review
- Human intestinal MUC17 mucin augments intestinal cell restitution and enhances healing of experimental colitis.The international journal of biochemistry & cell biology · 2010Article
- Cellular localization, binding sites, and pharmacologic effects of TFF3 in experimental colitis in mice.Digestive diseases and sciences · 2007Article
- Systemically administered trefoil factors are secreted into the gastric lumen and increase the viscosity of gastric contents.British journal of pharmacology · 2006Article
- Expression profiling reveals novel innate and inflammatory responses in the jejunal epithelial compartment during infection with Trichinella spiralis.Infection and immunity · 2004Article
- A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells.The Journal of clinical investigation · 1999Article
- Goblet-cell-specific transcription of mouse intestinal trefoil factor gene results from collaboration of complex series of positive and negative regulatory elements.The Biochemical journal · 1999Article
- Article
- Expression of intestinal trefoil factor mRNA is downregulated during progression of colorectal carcinomas.Journal of clinical pathology · 1997Article
- The trefoil gene maps to mouse chromosome 17.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis.The Biochemical journal · 1996Article
- Cloning of the cDNAs for mast-cell chymases from the jejunum of Mongolian gerbils, Meriones unguiculatus, and their sequence similarities with chymases expressed in the connective-tissue mast cells of mice and rats.The Biochemical journal · 1996Article
- Molecular aspects of restitution: functions of trefoil peptides.The Yale journal of biology and medicineArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A cDNA encoding mouse intestinal trefoil factor (mITF) was successfully cloned and sequenced from the small intestine of C57BL/6 mouse by using the combination of reverse transcription-PCR and rapid amplification of cDNA ends methods. The gene was, similar to rat and human ITFs, mainly expressed in the small and large intestine. The mITF expression was up-regulated during the recovery phase after depletion of goblet cells in acetic acid-induced colitis. On the other hand, the expression in the jejunum was not altered, while goblet cell hyperplasia was induced by Nippostrongylus brasiliensis infection. These results suggest that the mITF expression did not simply correlate with the number of goblet cells. The mITF may play an important role in the maintenance and repair of mucosal function of the rectum. Additionally, the mITF in the jejunum may play a role in alteration of the physicochemical nature of goblet cell mucins, thereby affecting the establishment of intestinal helminths.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.