ArticleProceedings of the National Academy of Sciences of the United States of America1995
Characterization and localization of the cytoplasmic dynein heavy chain in Aspergillus nidulans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 115 citations in OpenAlex.
- VezA/vezatin facilitates proper assembly of the dynactin complex in vivo.Cell reports · 2024Article
- Small Sized Yet Powerful: Nuclear Distribution C Proteins in Plants.Plants (Basel, Switzerland) · 2023Review
- Dynein activation in vivo is regulated by the nucleotide states of its AAA3 domain.Current biology : CB · 2021Article
- LIS1 regulates cargo-adapter-mediated activation of dynein by overcoming its autoinhibition in vivo.The Journal of cell biology · 2019Article
- NudC regulates photoreceptor disk morphogenesis and rhodopsin localization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- p25 of the dynactin complex plays a dual role in cargo binding and dynactin regulation.The Journal of biological chemistry · 2018Article
- The actin capping protein in Aspergillus nidulans enhances dynein function without significantly affecting Arp1 filament assembly.Scientific reports · 2018Article
- Endocytic recycling via the TGN underlies the polarized hyphal mode of life.PLoS genetics · 2018Article
- Discovery of a vezatin-like protein for dynein-mediated early endosome transport.Molecular biology of the cell · 2015Article
- HookA is a novel dynein-early endosome linker critical for cargo movement in vivo.The Journal of cell biology · 2014Article
- Identification of a novel site in the tail of dynein heavy chain important for dynein function in vivo.The Journal of biological chemistry · 2013Article
- Analyses of dynein heavy chain mutations reveal complex interactions between dynein motor domains and cellular dynein functions.Genetics · 2012Article
- Development of monoclonal antibodies to recombinant terrelysin and characterization of expression in Aspergillus terreus.Journal of medical microbiology · 2012Article
- Monoclonal antibodies to hyphal exoantigens derived from the opportunistic pathogen Aspergillus terreus.Clinical and vaccine immunology : CVI · 2011Article
- The p25 subunit of the dynactin complex is required for dynein-early endosome interaction.The Journal of cell biology · 2011Article
- Characterization of Aspergillus nidulans DidB Did2, a non-essential component of the multivesicular body pathway.Fungal genetics and biology : FG & B · 2010Article
- Dynein light intermediate chain in Aspergillus nidulans is essential for the interaction between heavy and intermediate chains.The Journal of biological chemistry · 2009Article
- Regulators of the cytoplasmic dynein motor.Nature reviews. Molecular cell biology · 2009Review
- The Aspergillus nidulans kinesin-3 UncA motor moves vesicles along a subpopulation of microtubules.Molecular biology of the cell · 2009Article
- Dynein light intermediate chain: an essential subunit that contributes to spindle checkpoint inactivation.Molecular biology of the cell · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migration of nuclei throughout the mycelium is essential for the growth and differentiation of filamentous fungi. In Aspergillus nidulans, the nudA gene, which is involved in nuclear migration, encodes a cytoplasmic dynein heavy chain. In this paper we use antibodies to characterize the Aspergillus cytoplasmic dynein heavy chain (ACDHC) and to show that the ACDHC is concentrated at the growing tip of the fungal mycelium. We demonstrate that four temperature-sensitive mutations in the nudA gene result in a striking decrease in ACDHC protein. Cytoplasmic dynein has been implicated in nuclear division in animal cells. Because the temperature-sensitive nudA mutants are able to grow slowly with occasional nuclei found in the mycelium and are able to undergo nuclear division, we have created a deletion/disruption nudA mutation and a tightly downregulated nudA mutation. These mutants exhibit a phenotype very similar to that of the temperature-sensitive nudA mutants with respect to growth, nuclear distribution, and nuclear division. This suggests that there are redundant backup motor proteins for both nuclear migration and nuclear division.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.