ArticleProceedings of the National Academy of Sciences of the United States of America1995
Specificity of dimer formation in tropomyosins: influence of alternatively spliced exons on homodimer and heterodimer assembly.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 74 citations in OpenAlex.
- Article
- Characterization of Alternative Splicing in High-Risk Wilms' Tumors.International journal of molecular sciences · 2024Article
- Allergen Valency, Dose, and FcεRI Occupancy Set Thresholds for Secretory Responses to Pen a 1 and Motivate Design of Hypoallergens.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Polymorphism in tropomyosin structure and function.Journal of muscle research and cell motility · 2013Review
- Tropomyosin variants describe distinct functional subcellular domains in differentiated vascular smooth muscle cells.American journal of physiology. Cell physiology · 2011Article
- Tropomyosin is an interaction partner of the Drosophila coiled coil protein yuri gagarin.Experimental cell research · 2011Article
- New insights into the regulation of the actin cytoskeleton by tropomyosin.International review of cell and molecular biology · 2010Review
- Human diploid fibroblasts are resistant to MEK/ERK-mediated disruption of the actin cytoskeleton and invasiveness stimulated by Ras.Oncogene · 2005Article
- Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta.Oncogene · 2005Article
- A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells.Molecular biology of the cell · 2004Article
- Specification of actin filament function and molecular composition by tropomyosin isoforms.Molecular biology of the cell · 2003Article
- Canine mesenteric artery and vein convey no difference in the content of major contractile proteins.BMC physiology · 2002Article
- Nucleocytoplasmic shuttling: a novel in vivo property of antisense phosphorothioate oligodeoxynucleotides.Nucleic acids research · 2000Article
- Externalization of tropomyosin isoform 5 in colon epithelial cells.Clinical and experimental immunology · 1999Article
- The PDZ domain of the LIM protein enigma binds to beta-tropomyosin.Molecular biology of the cell · 1999Article
- Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Review
- Tropomyosin-2 cDNA lacking the 3' untranslated region riboregulator induces growth inhibition of v-Ki-ras-transformed fibroblasts.Molecular biology of the cell · 1997Article
- Lck regulates Vav activation of members of the Rho family of GTPases.Molecular and cellular biology · 1997Article
- Identification of a novel Rac1-interacting protein involved in membrane ruffling.The EMBO journal · 1996Article
- Interior decoration: tropomyosin in actin dynamics and cell migration.Cell adhesion & migrationReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Tropomyosins consist of nearly 100% alpha-helix and assemble into parallel and in-register coiled-coil dimers. In vitro it has been established that nonmuscle as well as native muscle tropomyosins can form homodimers. However, a mixture of muscle alpha and beta tropomyosin subunits results in the formation of the thermodynamically more stable alpha/beta heterodimer. Although the assembly preference of the muscle tropomyosin heterodimer can be understood thermodynamically, the presence of multiple tropomyosin isoforms expressed in nonmuscle cells points toward a more complex principle for determining dimer formation. We have investigated the dimerization of rat tropomyosins in living cells by the use of epitope tagging with a 16-aa sequence of the influenza hemagglutinin. Employing transfection and immunoprecipitation techniques, we have analyzed the dimers formed by muscle and nonmuscle tropomyosins in rat fibroblasts. We demonstrate that the information for homo- versus heterodimerization is contained within the tropomyosin molecule itself and that the information for the selectivity is conferred by the alternatively spliced exons. These results have important implications for models of the regulation of cytoskeletal dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.