ArticleProceedings of the National Academy of Sciences of the United States of America1995
DNA loops induced by cooperative binding of transcriptional activator proteins and preinitiation complexes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 29 citations in OpenAlex.
- Global re-wiring of p53 transcription regulation by the hepatitis B virus X protein.Molecular oncology · 2016Article
- Expression of matrix metalloproteinase (MMP)-2, MMP-9, and tissue inhibitor of MMP (TIMP)-1 in conjunctival melanomas and clinical implications.Japanese journal of ophthalmology · 2010Article
- Loops in DNA: an overview of experimental and theoretical approaches.The European physical journal. E, Soft matter · 2006Review
- Transcription initiation from a poly(dA) tract.Nucleic acids research · 1998Article
- The transcription activation domains of Fos and Jun induce DNA bending through electrostatic interactions.The EMBO journal · 1997Article
- Structural basis of DNA bending and oriented heterodimer binding by the basic leucine zipper domains of Fos and Jun.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Fos and Jun bend the AP-1 site: effects of probe geometry on the detection of protein-induced DNA bending.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
DNA conformational changes are essential for the assembly of multiprotein complexes that contact several DNA sequence elements. An approach based on atomic force microscopy was chosen to visualize specific protein-DNA interactions occurring on eukaryotic class II nuclear gene promoters. Here we report that binding of the transcription regulatory protein Jun to linearized plasmid DNA containing the consensus AP-1 binding site upstream of a class II gene promoter leads to bending of the DNA template. This binding of Jun was found to be essential for the formation of preinitiation complexes (PICs). The cooperative binding of Jun and PIC led to looping of DNA at the protein binding sites. These loops were not seen in the absence of either PICs, Jun, or the AP-1 binding site, suggesting a direct interaction between DNA-bound Jun homodimers and proteins bound to the core promoter. This direct visualization of functional transcriptional complexes confirms the theoretical predictions for the mode of gene regulation by trans-activating proteins.
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Registered trials
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