ArticleProceedings of the National Academy of Sciences of the United States of America1995
Testis/brain RNA-binding protein attaches translationally repressed and transported mRNAs to microtubules.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 107 citations in OpenAlex.
- Systematic mRNA interactome analysis reconceptualizes translational quiescence in bovine sperm.Communications biology · 2025Article
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- Rapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells.Scientific reports · 2018Article
- Learning induces the translin/trax RNase complex to express activin receptors for persistent memory.eLife · 2017Article
- Conformational transitions in human translin enable nucleic acid binding.Nucleic acids research · 2013Article
- Low-resolution structure of Drosophila translin.FEBS open bio · 2012Article
- Neuronal expression, cytosolic localization, and developmental regulation of the organic solute carrier partner 1 in the mouse brain.Histochemistry and cell biology · 2011Article
- Molecular biological features of male germ cell differentiation.Reproductive medicine and biology · 2007Review
- Functional characterization of Drosophila Translin and Trax.Genetics · 2006Article
- Behavioral and neurochemical alterations in mice lacking the RNA-binding protein translin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2.Molecular biology of the cell · 2005Article
- Cloning and characterization of the Schizosaccharomyces pombe homologs of the human protein Translin and the Translin-associated protein TRAX.Nucleic acids research · 2005Article
- RNA transport and local control of translation.Annual review of cell and developmental biology · 2005Review
- The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes.Molecular and cellular biology · 2003Article
- Intercellular organelle traffic through cytoplasmic bridges in early spermatids of the rat: mechanisms of haploid gene product sharing.Molecular biology of the cell · 2003Article
- Candidate RNA-binding proteins regulating extrasomatic mRNA targeting and translation in mammalian neurons.Molecular neurobiology · 2002Review
- Altering the GTP binding site of the DNA/RNA-binding protein, Translin/TB-RBP, decreases RNA binding and may create a dominant negative phenotype.Nucleic acids research · 2001Article
- Sequence-independent assembly of spermatid mRNAs into messenger ribonucleoprotein particles.Molecular and cellular biology · 1999Article
- Dimerization of the testis brain RNA-binding protein (translin) is mediated through its C-terminus and is required for DNA- and RNA-binding.Nucleic acids research · 1998Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We have previously identified a testicular phosphoprotein that binds to highly conserved sequences (Y and H elements) in the 3' untranslated regions (UTRs) of testicular mRNAs and suppresses in vitro translation of mRNA constructs that contain these sequences. This protein, testis/brain RNA-binding protein (TB-RBP) also is abundant in brain and binds to brain mRNAs whose 3' UTRs contain similar sequences. Here we show that TB-RBP binds specific mRNAs to microtubules (MTs) in vitro. When TB-RBP is added to MTs reassembled from either crude brain extracts or from purified tubulin, most of the TB-RBP binds to MTs. The association of TB-RBP with MTs requires the assembly of MTs and is diminished by colcemid, cytochalasin D, and high levels of salt. Transcripts from the 3' UTRs of three mRNAs that contain the conserved sequence elements (transcripts for protamine 2, tau protein, and myelin basic protein) are linked by TB-RBP to MTs, whereas transcripts that lack the conserved sequences do not bind TB-RBP. We conclude that TB-RBP serves as an attachment protein for the MT association of specific mRNAs. Considering its ability to arrest translation in vitro, we propose that TB-RBP functions in the storage and transportation of mRNAs to specific intracellular sites where they are translated.
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Registered trials
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