ArticleProceedings of the National Academy of Sciences of the United States of America1995
A nerve growth factor peptide retards seizure development and inhibits neuronal sprouting in a rat model of epilepsy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 71 citations in OpenAlex.
- The Impacts of Surgery and Intracerebral Electrodes in C57BL/6J Mouse Kainate Model of Epileptogenesis: Seizure Threshold, Proteomics, and Cytokine Profiles.Frontiers in neurology · 2021Article
- Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1.Molecular medicine reports · 2020Article
- Neurotrophin receptors expression in mesial temporal lobe epilepsy with and without psychiatric comorbidities and their relation with seizure type and surgical outcome.Acta neuropathologica communications · 2014Article
- Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice.The Journal of clinical investigation · 2011Article
- Prenatal choline supplementation attenuates neuropathological response to status epilepticus in the adult rat hippocampus.Neurobiology of disease · 2008Article
- TrkB receptor ligands promote activity-dependent inhibitory synaptogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen, and skeletal muscle dystrophy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Selective inhibition of kindling development by intraventricular administration of TrkB receptor body.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Nonobligate role of early or sustained expression of immediate-early gene proteins c-fos, c-jun, and Zif/268 in hippocampal mossy fiber sprouting.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Nerve growth factor accelerates seizure development, enhances mossy fiber sprouting, and attenuates seizure-induced decreases in neuronal density in the kindling model of epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kindling, an animal model of epilepsy wherein seizures are induced by subcortical electrical stimulation, results in the upregulation of neurotrophin mRNA and protein in the adult rat forebrain and causes mossy fiber sprouting in the hippocampus. Intraventricular infusion of a synthetic peptide mimic of a nerve growth factor domain that interferes with the binding of neurotrophins to their receptors resulted in significant retardation of kindling and inhibition of mossy fiber sprouting. These findings suggest a critical role for neurotrophins in both kindling and kindling-induced synaptic reorganization.
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