ArticleProceedings of the National Academy of Sciences of the United States of America1995
The amino-terminal domain of the prokaryotic enhancer-binding protein XylR is a specific intramolecular repressor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Measuring Communication in Microbial Biofilms in Response to Antibiotics, Phytochemicals and Stressors.Antioxidants (Basel, Switzerland) · 2026Article
- Transcription factor-based biosensors enlightened by the analyte.Frontiers in microbiology · 2015Review
- The role of bacterial enhancer binding proteins as specialized activators of σ54-dependent transcription.Microbiology and molecular biology reviews : MMBR · 2012Review
- Promoter recognition and activation by the global response regulator CbrB in Pseudomonas aeruginosa.Journal of bacteriology · 2011Article
- Protein engineering of the transcriptional activator FhlA To enhance hydrogen production in Escherichia coli.Applied and environmental microbiology · 2009Article
- Integration of signals through Crc and PtsN in catabolite repression of Pseudomonas putida TOL plasmid pWW0.Applied and environmental microbiology · 2005Article
- Physiological stress of intracellular Shigella flexneri visualized with a metabolic sensor fused to a surface-reporter system.FEBS letters · 2005Article
- Genetic evidence that catabolites of the Entner-Doudoroff pathway signal C source repression of the sigma54 Pu promoter of Pseudomonas putida.Journal of bacteriology · 2004Article
- Bacterial transcriptional regulators for degradation pathways of aromatic compounds.Microbiology and molecular biology reviews : MMBR · 2004Review
- Sigma 54 levels and physiological control of the Pseudomonas putida Pu promoter.Journal of bacteriology · 2003Article
- Enhancer-binding proteins HrpR and HrpS interact to regulate hrp-encoded type III protein secretion in Pseudomonas syringae strains.Journal of bacteriology · 2001Article
- Monitoring intracellular levels of XylR in Pseudomonas putida with a single-chain antibody specific for aromatic-responsive enhancer-binding proteins.Journal of bacteriology · 2001Article
- New insights into the activation of o-xylene biodegradation in Pseudomonas stutzeri OX1 by pathway substrates.EMBO reports · 2001Article
- An active role for a structured B-linker in effector control of the sigma54-dependent regulator DmpR.The EMBO journal · 2001Article
- Transcriptional organization and dynamic expression of the hbpCAD genes, which encode the first three enzymes for 2-hydroxybiphenyl degradation in Pseudomonas azelaica HBP1.Journal of bacteriology · 2001Article
- Identification of an effector specificity subregion within the aromatic-responsive regulators DmpR and XylR by DNA shuffling.Journal of bacteriology · 2000Article
- HbpR, a new member of the XylR/DmpR subclass within the NtrC family of bacterial transcriptional activators, regulates expression of 2-hydroxybiphenyl metabolism in Pseudomonas azelaica HBP1.Journal of bacteriology · 2000Article
- The C-terminal domain of Sin1 interacts with the SWI-SNF complex in yeast.Molecular and cellular biology · 1998Article
- Activation and repression of transcription at the double tandem divergent promoters for the xylR and xylS genes of the TOL plasmid of Pseudomonas putida.Journal of bacteriology · 1998Article
- Expression, inducer spectrum, domain structure, and function of MopR, the regulator of phenol degradation in Acinetobacter calcoaceticus NCIB8250.Journal of bacteriology · 1997Article
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Abstract
The mechanism under which the signal-reception amino-terminal portion (A domain) of the prokaryotic enhancer-binding protein XylR controls the activity of the regulator has been investigated through complementation tests in vivo, in which the various protein segments were produced as independent polypeptides. Separate expression of the A domain repressed the otherwise constitutive activity of a truncated derivative of XylR deleted of its A domain (XylR delta A). Such inhibition was not released by m-xylene, the natural inducer of the system. Repression caused by the A domain was specific for XylR because it did not affect activation of the sigma 54 promoter PnifH by a derivative of its cognate regulator, NifA, deleted of its own A domain. The A domain was also unable to repress the activity of a NifA-XylR hybrid protein resulting from fusing two-thirds of the central domain of NifA to the carboxyl-terminal third of XylR, which includes its DNA-binding domain. The inhibitory effect caused by the A domain of XylR on XylR delta A seems, therefore, to result from specific interactions in trans between the two truncated proteins and not from mere hindering of an activating surface.
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