ArticleProceedings of the National Academy of Sciences of the United States of America1995
Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 107 citations in OpenAlex.
- Exhaustion‑like dysfunction of T and NKT cells in an X‑linked severe combined immunodeficiency patient with maternal engraftment by single‑cell analysis.International journal of molecular medicine · 2023Article
- Generation of novel Il2rg-knockout mice with clustered regularly interspaced short palindromic repeats (CRISPR) and Cas9.Experimental animals · 2020Article
- IL-2 modulates Th2 cell responses to glucocorticosteroid: A cause of persistent type 2 inflammation?Immunity, inflammation and disease · 2019Article
- The Common Cytokine Receptor γ Chain Family of Cytokines.Cold Spring Harbor perspectives in biology · 2018Review
- The B cell antigen receptor and overexpression of MYC can cooperate in the genesis of B cell lymphomas.PLoS biology · 2008Article
- Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon.FEBS letters · 2007Article
- STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression.Oncogene · 2004Article
- Differential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation.Molecular and cellular biology · 2000Article
- Review
- Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteins.The EMBO journal · 1999Article
- Expression of the c-myc proto-oncogene is essential for HIV-1 infection in activated T cells.The Journal of experimental medicine · 1999Article
- STAT3 is required for the gp130-mediated full activation of the c-myc gene.The Journal of experimental medicine · 1999Article
- Recent advances in the understanding of interleukin-2 signal transduction.Journal of clinical immunology · 1998Review
- A critical role for cyclin C in promotion of the hematopoietic cell cycle by cooperation with c-Myc.Molecular and cellular biology · 1998Article
- Cytokine-induced survival of activated T cells in vitro and in vivo.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway.Genes & development · 1998Article
- The hyper-IgM (HIM) syndrome.Springer seminars in immunopathology · 1998Review
- The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
The interleukin 2 receptor (IL-2R) consists of three subunits, the IL-2R alpha, IL-2R beta c, and IL-2R gamma c chains. Two Janus family protein tyrosine kinases (PTKs), Jak1 and Jak3, were shown to associate with IL-2R beta c and IL-2R gamma c, respectively, and their PTK activities are increased after IL-2 stimulation. A Jak3 mutant with truncation of the C-terminal PTK domain lacks its intrinsic kinase activity but can still associate with IL-2R gamma c. In a hematopoietic cell line, F7, that responds to either IL-2 or IL-3, overexpression of this Jak3 mutant results in selective inhibition of the IL-2-induced activation of Jak1/Jak3 PTKs and of cell proliferation. Of the three target nuclear protooncogenes of the IL-2 signaling, c-fos and c-myc genes, but not the bcl-2 gene, were found to be impaired. On the other hand, overexpression of the dominant negative form of the IL-2R gamma c chain, which lacks most of its cytoplasmic domain, in F7 cells resulted in the inhibition of all three protooncogenes. These results provide a further molecular basis for the critical role of Jak3 in IL-2 signaling and also suggest a Jak PTK-independent signaling pathway(s) for the bcl-2 gene induction by IL-2R.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.