ArticleProceedings of the National Academy of Sciences of the United States of America1995
Retinoid X receptor alpha forms tetramers in solution.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Retinoid-X receptor action and disruption in development.Developmental biology · 2026Review
- New structural insights into the control of the retinoic acid receptors RAR/RXR by DNA, ligands, and transcriptional coregulators.Nucleic acids research · 2025Article
- The intrinsically disordered AB region: a key modulator of the molecular properties of human RXRγ.Cell communication and signaling : CCS · 2025Article
- Article
- A structural signature motif enlightens the origin and diversification of nuclear receptors.PLoS genetics · 2021Article
- Glucocorticoid receptor quaternary structure drives chromatin occupancy and transcriptional outcome.Genome research · 2019Article
- Retinoid X Receptor Antagonists.International journal of molecular sciences · 2018Review
- Translation of a Tissue-Selective Rexinoid, UAB30, to the Clinic for Breast Cancer Prevention.Current topics in medicinal chemistry · 2017Review
- β-Apo-13-carotenone regulates retinoid X receptor transcriptional activity through tetramerization of the receptor.The Journal of biological chemistry · 2014Article
- Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site.Chemistry & biology · 2014Article
- Targeting nuclear receptors with marine natural products.Marine drugs · 2014Review
- Defining the communication between agonist and coactivator binding in the retinoid X receptor α ligand binding domain.The Journal of biological chemistry · 2014Article
- Retinoic acid actions through mammalian nuclear receptors.Chemical reviews · 2014Review
- Systems biophysics of gene expression.Biophysical journal · 2013Review
- Control of gene expression by modulated self-assembly.Nucleic acids research · 2011Article
- Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.The Journal of biological chemistry · 2011Article
- Article
- Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptor's oligomeric switch.Journal of molecular biology · 2010Article
- Mutations in the DNA-binding domain of NR2E3 affect in vivo dimerization and interaction with CRX.PloS one · 2009Article
- Interleukin-22 forms dimers that are recognized by two interleukin-22R1 receptor chains.Biophysical journal · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Protein-protein interactions allow the retinoid X receptor (RXR) to bind to cognate DNA as a homo- or a heterodimer and to participate in mediating the effects of a variety of hormones on gene transcription. Here we report a systematic study of the oligomeric state of RXR in the absence of a DNA template. We have used electrophoresis under nondenaturing conditions and chemical crosslinking to show that in solution, RXR alpha forms homodimers as well as homotetramers. The dissociation constants governing dimer and tetramer formation were estimated by fluorescence anisotropy studies. The results indicate that RXR tetramers are formed with a high affinity and that at protein concentrations higher than about 70 nM, tetramers will constitute the predominant species. Tetramer formation may provide an additional level of the regulation of gene transcription mediated by RXRs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.