ArticleProceedings of the National Academy of Sciences of the United States of America1995
Aromatic-L-amino-acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a beta-cell autoantigen.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 97 citations in OpenAlex.
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- Gut Bacteria and Neuropsychiatric Disorders.Microorganisms · 2021Review
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- Pathogenic and Protective Autoantibodies in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).Antibodies (Basel, Switzerland) · 2017Review
- Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis.Journal of the American Society of Nephrology : JASN · 2016Article
- Type 1 Diabetes in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Syndrome (APECED): A "Rare" Manifestation in a "Rare" Disease.International journal of molecular sciences · 2016Review
- Dopamine pathway gene variants may modulate cognitive performance in the DHS - Mind Study.Brain and behavior · 2016Article
- Type 1 diabetes and polyglandular autoimmune syndrome: A review.World journal of diabetes · 2015Review
- Identification of TPIT and other novel autoantigens in lymphocytic hypophysitis: immunoscreening of a pituitary cDNA library and development of immunoprecipitation assays.European journal of endocrinology · 2012Article
- Novel biomarkers in type 1 diabetes.The review of diabetic studies : RDS · 2012Review
- Release of membrane-associated L-dopa decarboxylase from human cells.Neurochemical research · 2011Article
- N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Pulmonary autoimmunity as a feature of autoimmune polyendocrine syndrome type 1 and identification of KCNRG as a bronchial autoantigen.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Absence of autoantibodies connected to autoimmune polyendocrine syndrome type I and II and Addison's disease in girls and women with Turner syndrome.Journal of negative results in biomedicine · 2007Article
- Lymphocytic hypophysitis: report of two biopsy-proven cases and one suspected case with pituitary autoantibodies.Journal of endocrinological investigation · 2007Article
- Pituitary autoantibodies in autoimmune polyendocrine syndrome type 1.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Pyridoxal phosphatase is a novel cancer autoantigen in the central nervous system.British journal of cancer · 2004Article
- Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease.Journal of autoimmune diseases · 2004Article
- L-DOPA decarboxylase association with membranes in mouse brain.Neurochemical research · 2001Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different autoantigens are thought to be involved in the pathogenesis of insulin-dependent diabetes mellitus, and they may account for the variation in the clinical presentation of the disease. Sera from patients with autoimmune polyendocrine syndrome type I contain autoantibodies against the beta-cell proteins glutamate decarboxylase and an unrelated 51-kDa antigen. By screening of an expression library derived from rat insulinoma cells, we have identified the 51-kDa protein as aromatic-L-amino-acid decarboxylase (EC 4.1.1.28). In addition to the previously published full-length cDNA, forms coding for a truncated and an alternatively spliced version were identified. Aromatic L-amino acid decarboxylase catalyzes the decarboxylation of L-5-hydroxytryptophan to serotonin and that of L-3,4-dihydroxyphenylalanine to dopamine. Interestingly, pyridoxal phosphate is the cofactor of both aromatic L-amino acid decarboxylase and glutamate decarboxylase. The biological significance of the neurotransmitters produced by the two enzymes in the beta cells remains largely unknown.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.