ReviewProceedings of the National Academy of Sciences of the United States of America1995
Genetic analysis of type 1 diabetes using whole genome approaches.
Review in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 253 citations in OpenAlex.
- Insights into non-autoimmune type 1 diabetes with 13 novel loci in low polygenic risk score patients.Scientific reports · 2021Article
- Genetic architecture of type 1 diabetes with low genetic risk score informed by 41 unreported loci.Communications biology · 2021Article
- Differential HLA Association of GAD65 and IA2 Autoantibodies in North Indian Type 1 Diabetes Patients.Journal of diabetes research · 2021Article
- A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes.JCI insight · 2018Article
- TCR transgenic mice reveal the impact of type 1 diabetes loci on early and late disease checkpoints.Immunology and cell biology · 2016Article
- A flexible approach for the analysis of rare variants allowing for a mixture of effects on binary or quantitative traits.PLoS genetics · 2013Article
- Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes.Genes and immunity · 2012Article
- Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk.Diabetologia · 2012Article
- Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma.Clinical and experimental immunology · 2012Review
- From markers to molecular mechanisms: type 1 diabetes in the post-GWAS era.The review of diabetic studies : RDS · 2012Review
- Immunogenetic mechanisms leading to thyroid autoimmunity: recent advances in identifying susceptibility genes and regions.Current genomics · 2011Article
- Article
- Estimation of genetic risk for Type 1 diabetes mellitus in newborns on dried blood spot.Journal of endocrinological investigation · 2010Article
- Spontaneous rodent models of diabetes and diabetic retinopathy.International journal of ophthalmology · 2010Article
- Increased prevalence of autoimmunity in patients with white spot syndromes and their family members.Archives of ophthalmology (Chicago, Ill. : 1960) · 2009Article
- HLA and infectious diseases.Clinical microbiology reviews · 2009Review
- Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach.Diabetes, obesity & metabolism · 2009Article
- Understanding genetic factors in idiopathic scoliosis, a complex disease of childhood.Current genomics · 2008Article
- Radioiodinated naphthylalanine derivatives targeting pancreatic beta cells in normal and nonobese diabetic mice.Experimental diabetes research · 2008Article
- Study design of the Trial to Reduce IDDM in the Genetically at Risk (TRIGR).Pediatric diabetes · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Whole genome linkage analysis of type 1 diabetes using affected sib pair families and semi-automated genotyping and data capture procedures has shown how type 1 diabetes is inherited. A major proportion of clustering of the disease in families can be accounted for by sharing of alleles at susceptibility loci in the major histocompatibility complex on chromosome 6 (IDDM1) and at a minimum of 11 other loci on nine chromosomes. Primary etiological components of IDDM1, the HLA-DQB1 and -DRB1 class II immune response genes, and of IDDM2, the minisatellite repeat sequence in the 5' regulatory region of the insulin gene on chromosome 11p15, have been identified. Identification of the other loci will involve linkage disequilibrium mapping and sequencing of candidate genes in regions of linkage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.