ArticleNucleic acids research1995
Relative exon affinities and suboptimal splice site signals lead to non-equivalence of two cassette exons.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Strategies of positron emission tomography (PET) tracer development for imaging of tau and α-synuclein in neurodegenerative disorders.RSC medicinal chemistry · 2025Review
- Untangling the role of tau in sex hormone responsive cancers: lessons learnt from Alzheimer's disease.Clinical science (London, England : 1979) · 2024Review
- Human Tau Aggregates Are Permissive to Protein Synthesis-Dependent Memory inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- SR Protein Kinase 1 Inhibition by TAF15.Cells · 2022Article
- Tau Isoforms: Gaining Insight intoInternational journal of molecular sciences · 2022Review
- Tau and Alpha Synuclein Synergistic Effect in Neurodegenerative Diseases: When the Periphery Is the Core.International journal of molecular sciences · 2020Review
- Immunotherapy Targeting Neurodegenerative Proteinopathies: α-Synucleinopathies and Tauopathies.Journal of movement disorders · 2020Article
- Altered Levels and Isoforms of Tau and Nuclear Membrane Invaginations in Huntington's Disease.Frontiers in cellular neuroscience · 2019Review
- Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders.Molecular neurodegeneration · 2017Article
- Review
- Evidence for disulfide bonds in SR Protein Kinase 1 (SRPK1) that are required for activity and nuclear localization.PloS one · 2017Article
- Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.Human molecular genetics · 2015Article
- Ketamine induces tau hyperphosphorylation at serine 404 in the hippocampus of neonatal rats.Neural regeneration research · 2013Article
- The involvement of cholinergic neurons in the spreading of tau pathology.Frontiers in neurology · 2013Article
- Potential contribution of exosomes to the prion-like propagation of lesions in Alzheimer's disease.Frontiers in physiology · 2012Article
- Tau exon 10 alternative splicing and tauopathies.Molecular neurodegeneration · 2008Article
- Tau isoforms expression in transgenic mouse model of amyotrophic lateral sclerosis.Neurochemical research · 2006Article
- Gene-environment interplay in neurogenesis and neurodegeneration.Neurotoxicity research · 2004Review
- Tau in neurodegenerative diseases: tau phosphorylation and assembly.Neurotoxicity research · 2004Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Tau is a microtubule-associated protein whose transcript undergoes complex regulated splicing in the mammalian nervous system. Exons 2 and 3 of the gene are alternatively spliced cassettes in which exon 3 never appears independently of exon 2. Expression of tau minigene constructs in cells indicate that exon 2 resembles a constitutive exon, while a suboptimal branch point connected to exon 3 inhibits inclusion of exon 3 in the mRNA. Splicing of the two tau exons is controlled by their relative affinities for each other versus the affinities of their flanking exons for them.
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