Evidence map›Paper›PMID 7567456›Full record

ArticleNucleic acids research1995

Repair of plasmid and genomic DNA in a rad7 delta mutant of yeast.

J P Mueller, M J Smerdon

Open access · bronzeAbstract read
In one paragraph

Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Transcription-coupled repair in RNA polymerase I-transcribed genes of yeast.Proceedings of the National Academy of Sciences of the United States of America · 2002
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

J P MuellerDepartment of Biochemistry and Biophysics, Washington State University, Pullman 99164-4660, USA.
M J Smerdon
Washington State University · US

Funding

Repair of Carcinogen Damaged DNA in Human ChromatinR37ES002614 · NIEHS · WASHINGTON STATE UNIVERSITY · PI SMERDON, MICHAEL J · 2001 to 2010
$4.0M
REPAIR OF CARCINOGEN-DAMAGED DNA IN HUMAN CHROMATINR01ES002614 · NIEHS · WASHINGTON STATE UNIVERSITY · PI SMERDON, MICHAEL J, WYRICK, JOHN J · 1985 to 2015
$2.5M
NIEHS NIH HHS ES02614
6 · The paper itself

Abstract

Repair of UV-induced cyclobutane pyrimidine dimers (CPDs) was examined in a yeast plasmid of known chromatin structure and in genomic DNA in a radiation-sensitive deletion mutant of yeast, rad7 delta, and its isogenic wild-type strain. A whole plasmid repair assay revealed that only approximately 50% of the CPDs in plasmid DNA are repaired after 6 h in this mutant, compared with almost 90% repaired in wild-type. Using a site-specific repair assay on 44 individual CPD sites within the plasmid we found that repair in the rad7 delta mutant occurred primarily in the transcribed regions of each strand of the plasmid, however, the rate of repair at nearly all sites measured was less than in the wild-type. There was no apparent correlation between repair rate and nucleosome position. In addition, approximately 55% of the CPDs in genomic DNA of the mutant are repaired during the 6 h period, compared with > 80% in the wild-type.

Indexed as

DNA-Binding ProteinsDNA RepairSaccharomyces cerevisiae ProteinsChromatinDNA DamageDNA, FungalFungal ProteinsPlasmidsPyrimidine DimersSaccharomyces cerevisiaeTranscription, GeneticUltraviolet RaysChromatinDNA-Binding ProteinsDNA, FungalFungal ProteinsPyrimidine DimersRAD7 protein, S cerevisiaeSaccharomyces cerevisiae Proteins

Identifiers

PMID7567456
PMCPMC307224
OpenAlexW2066288618

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.