ArticleNucleic acids research1995
A DNA binding factor (UBF) interacts with a positive regulatory element in the promoters of genes expressed during meiosis and vegetative growth in yeast.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Genome-wide expression profiling, in vivo DNA binding analysis, and probabilistic motif prediction reveal novel Abf1 target genes during fermentation, respiration, and sporulation in yeast.Molecular biology of the cell · 2008Article
- Genetic evidence for a SPO1-dependent signaling pathway controlling meiotic progression in yeast.Genetics · 2007Article
- Novel response to microtubule perturbation in meiosis.Molecular and cellular biology · 2005Article
- Yeast Ume6p repressor permits activator binding but restricts TBP binding at the HOP1 promoter.Nucleic acids research · 2003Article
- The origin of alternation of generations in land plants: a focus on matrotrophy and hexose transport.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2000Review
- Isolation of COM1, a new gene required to complete meiotic double-strand break-induced recombination in Saccharomyces cerevisiae.Genetics · 1997Article
- Analysis of a meiosis-specific URS1 site: sequence requirements and involvement of replication protein A.Molecular and cellular biology · 1997Article
- An Ssn6-Tup1-dependent negative regulatory element controls sporulation-specific expression of DIT1 and DIT2 in Saccharomyces cerevisiae.Molecular and cellular biology · 1997Article
- Participation of the yeast activator Abf1 in meiosis-specific expression of the HOP1 gene.Molecular and cellular biology · 1996Article
- Induction of meiosis in Saccharomyces cerevisiae depends on conversion of the transcriptional represssor Ume6 to a positive regulator by its regulated association with the transcriptional activator Ime1.Molecular and cellular biology · 1996Article
- UME6 is a central component of a developmental regulatory switch controlling meiosis-specific gene expression.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
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5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied the bipartite regulatory element UASH/URS1 in the promoter of HOP1, whose product is required for synapsis and correct pairing of homologous chromosomes during the first meiotic division. HOP1 is transcriptionally repressed by the URS1 motif during vegetative growth and induced during meiotic prophase by the UASH motif in cooperation with the bifunctional URS1 site, which is required for full induction of HOP1. While URS1 is bound in vitro by the Buf and Ume6 repressor proteins, we demonstrate for the first time by electrophoretic mobility shift assays and interference footprinting that the UASH site interacts in vitro with a novel factor called UBF (UASH binding factor) which is present in haploid and diploid cycling, as well as sporulating cells. Point mutations in the HOP1 UASH motif abolish UBF-dependent DNA binding activity in vitro and meiotic HOP1 gene expression in vivo. Furthermore, we show that UBF binds in vitro to UASH-like sequences in the promoter regions of several meiosis-specific and non-specific genes and propose that UBF mediates gene expression through its interaction with the UASH motif in both cycling and sporulating cells.
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