ArticleNucleic acids research1995
Variable pause positions of RNA polymerase II lie proximal to the c-myc promoter irrespective of transcriptional activity.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription.Transcription · 2015Article
- The Mediator complex and transcription elongation.Biochimica et biophysica acta · 2013Review
- Elongation dynamics shape bursty transcription and translation.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Alternative promoters determine tissue-specific expression profiles of the human microsomal epoxide hydrolase gene (EPHX1).Molecular pharmacology · 2005Article
- TFIIH operates through an expanded proximal promoter to fine-tune c-myc expression.Molecular and cellular biology · 2005Article
- Transition from initiation to promoter proximal pausing requires the CTD of RNA polymerase II.Nucleic acids research · 2005Article
- Stimulated initiation of mitogen-activated protein kinase phosphatase-1 (MKP-1) gene transcription involves the synergistic action of multiple cis-acting elements in the proximal promoter.The Biochemical journal · 2004Article
- RNA diversity has profound effects on the translation of neuronal nitric oxide synthase.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Nucleosomes are not necessary for promoter-proximal pausing in vitro on the Drosophila hsp70 promoter.Nucleic acids research · 1998Article
- Nucleosomal structures of c-myc promoters with transcriptionally engaged RNA polymerase II.Molecular and cellular biology · 1997Article
- Multiple single-stranded cis elements are associated with activated chromatin of the human c-myc gene in vivo.Molecular and cellular biology · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcriptional activation of the c-myc proto-oncogene is mediated by the transition of promoter proximal, paused RNA polymerase II (pol II) into a processive transcription mode. Using a transcription assay which allows the high resolution mapping of transcriptional complexes in intact nuclei, we have characterized the promoter proximal pause positions of pol II. Pol II paused in a nucleosome-free region close to the transcription start site as well as further downstream, between positions +17 and +52. These pause positions were detected in both transcriptionally active and inactive c-myc genes. Pharmacological inhibition of the C-terminal phosphorylation of the large subunit of pol II did not affect the paused transcription complexes, but had an inhibitory effect on transcription of nucleosomal DNA downstream of position +150. The different properties of pol II proximal and distal to the promoter suggest a model in which c-myc transcription is regulated by the activation of promoter bound polymerases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.