ArticleMolecular and cellular biology1995
Helix-loop-helix transcription factors mediate activation and repression of the p75LNGFR gene.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 43 citations in OpenAlex.
- Expression of alternative transcription factor 4 mRNAs and protein isoforms in the developing and adult rodent and human tissues.Frontiers in molecular neuroscience · 2022Article
- Transcriptional responses of cultured rat sympathetic neurons during BMP-7-induced dendritic growth.PloS one · 2011Article
- Egr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R.Neurobiology of aging · 2009Article
- UVB upregulates the bax promoter in immortalized human keratinocytes via ROS induction of Id3.Experimental dermatology · 2009Article
- Id2 protein is selectively upregulated by UVB in primary, but not in immortalized human keratinocytes and inhibits differentiation.Oncogene · 2005Article
- The basic helix-loop-helix differentiation factor Nex1/MATH-2 functions as a key activator of the GAP-43 gene.Journal of neurochemistry · 2003Article
- Mammalian achaete scute homolog 2 is expressed in the adult sciatic nerve and regulates the expression of Krox24, Mob-1, CXCR4, and p57kip2 in Schwann cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Constitutive overexpression of the basic helix-loop-helix Nex1/MATH-2 transcription factor promotes neuronal differentiation of PC12 cells and neurite regeneration.Journal of neuroscience research · 2002Article
- Expression of the bHLH transcription factor Tcf12 (ME1) gene is linked to the expansion of precursor cell populations during neurogenesis.Brain research. Gene expression patterns · 2002Article
- Identification of Id2 as a globin regulatory protein by representational difference analysis of K562 cells induced to express gamma-globin with a fungal compound.Molecular and cellular biology · 1999Article
- The neurobiology of Schwann cells.Brain pathology (Zurich, Switzerland) · 1999Review
- Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene.Molecular and cellular biology · 1997Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
Sequence analysis of rat and human low-affinity nerve growth factor receptor p75LNGFR gene promoter regions revealed a single E-box cis-acting element, located upstream of the major transcription start sites. Deletion analysis of the E-box sequence demonstrated that it significantly contributes to p75LNGFR promoter activity. This E box has a dual function; it mediates either activation or repression of the p75LNGFR promoter activity, depending on the interacting transcription factors. We showed that the two isoforms of the class A basic helix-loop-helix (bHLH) transcription factor ME1 (ME1a and ME1b), the murine homolog of the human HEB transcription factor, specifically repress p75LNGFR promoter activity. This repression can be released by coexpression of the HLH Id2 transcriptional regulator. In vitro analyses demonstrated that ME1a forms a stable complex with the p75LNGFR E box and likely competes with activating E-box-binding proteins. By using ME1a-overexpressing PC12 cells, we showed that the endogenous p75LNGFR gene is a target of ME1a repression. Together, these data demonstrate that the p75LNGFR E box and the interacting bHLH transcription factors are involved in the regulation of p75LNGFR gene expression. These results also show that class A bHLH transcription factors can repress and Id-like negative regulators can stimulate gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.