ArticleMolecular and cellular biology1995
Role of chromatin and Xenopus laevis heat shock transcription factor in regulation of transcription from the X. laevis hsp70 promoter in vivo.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 63 citations in OpenAlex.
- Targeting the Y/CCAAT box in cancer: YB-1 (YBX1) or NF-Y?Cell death and differentiation · 2013Review
- Wheat chloroplast targeted sHSP26 promoter confers heat and abiotic stress inducible expression in transgenic Arabidopsis Plants.PloS one · 2013Article
- Role of nuclear factor Y in stress-induced activation of the herpes simplex virus type 1 ICP0 promoter.Journal of virology · 2010Article
- TBP2 is a substitute for TBP in Xenopus oocyte transcription.BMC biology · 2009Article
- Nuclear factor Y is required for basal activation and chromatin accessibility of fibroblast growth factor receptor 2 promoter in osteoblast-like cells.The Journal of biological chemistry · 2009Article
- Analysis of chromatin structure in the control regions of the chlamydomonas HSP70A and RBCS2 genes.Plant molecular biology · 2005Article
- NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes.Molecular and cellular biology · 2005Article
- Retinoic acid receptor alpha fusion to PML affects its transcriptional and chromatin-remodeling properties.Molecular and cellular biology · 2003Article
- Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains.Molecular and cellular biology · 2002Article
- Molecular mechanisms of gene silencing mediated by DNA methylation.Molecular and cellular biology · 2002Article
- Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- MeCP2 driven transcriptional repression in vitro: selectivity for methylated DNA, action at a distance and contacts with the basal transcription machinery.Nucleic acids research · 2000Article
- NF-Y associates with H3-H4 tetramers and octamers by multiple mechanisms.Molecular and cellular biology · 1999Article
- AnCF, the CCAAT binding complex of Aspergillus nidulans, is essential for the formation of a DNase I-hypersensitive site in the 5' region of the amdS gene.Molecular and cellular biology · 1999Article
- Transcriptional repression by XPc1, a new Polycomb homolog in Xenopus laevis embryos, is independent of histone deacetylase.Molecular and cellular biology · 1999Article
- chk-YB-1b, a Y-box binding protein activates transcription from rat alpha1(I) procollagen gene promoter.The Biochemical journal · 1998Article
- Xenopus NF-Y pre-sets chromatin to potentiate p300 and acetylation-responsive transcription from the Xenopus hsp70 promoter in vivo.The EMBO journal · 1998Article
- Xenopus TFIIIA gene transcription is dependent on cis-element positioning and chromatin structure.Molecular and cellular biology · 1998Article
- Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription.Nature genetics · 1998Article
- Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase.The EMBO journal · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Xenopus laevis oocytes activate transcription from the Xenopus hsp70 promoter within a chromatin template in response to heat shock. Expression of exogenous Xenopus heat shock transcription factor 1 (XHSF1) causes the activation of the wild-type hsp70 promoter within chromatin. XHSF1 activates transcription at normal growth temperatures (18 degrees C), but heat shock (34 degrees C) facilitates transcriptional activation. Titration of chromatin in vivo leads to constitutive transcription from the wild-type hsp70 promoter. The Y box elements within the hsp70 promoter facilitate transcription in the presence or absence of chromatin. The presence of the Y box elements prevents the assembly of canonical nucleosomal arrays over the promoter and facilitates transcription. In a mutant hsp70 promoter lacking Y boxes, exogenous XHSF1 activates transcription from a chromatin template much more efficiently under heat shock conditions. Activation of transcription from the mutant promoter by exogenous XHSF1 correlates with the disappearance of a canonical nucleosomal array over the promoter. Chromatin structure on a mutant hsp70 promoter lacking Y boxes can restrict XHSF1 access; however, on both mutant and wild-type promoters, chromatin assembly can also restrict the function of the basal transcriptional machinery. We suggest that chromatin assembly has a physiological role in establishing a transcriptionally repressed state on the Xenopus hsp70 promoter in vivo.
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