ArticleMolecular and cellular biology1995
3'-end-forming signals of yeast mRNA.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Profiling heterologous 3' terminator-dependent expression variation inSynthetic and systems biotechnology · 2026Article
- Biological parts in yeast synthetic biology: from regulatory elements to predictive design platforms.FEMS yeast research · 2026Review
- Mix and Match: Promoters and Terminators for Tuning Gene Expression in the Methylotrophic YeastFrontiers in bioengineering and biotechnology · 2022Article
- Effects of sequence motifs in the yeast 3' untranslated region determined from massively parallel assays of random sequences.Genome biology · 2021Article
- Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.Nature structural & molecular biology · 2018Article
- Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex.eLife · 2017Article
- Cytoplasmic poly(A) binding protein-1 binds to genomically encoded sequences within mammalian mRNAs.RNA (New York, N.Y.) · 2016Article
- Global mapping of DNA conformational flexibility on Saccharomyces cerevisiae.PLoS computational biology · 2015Article
- Delineating the structural blueprint of the pre-mRNA 3'-end processing machinery.Molecular and cellular biology · 2014Review
- Sequence analysis of a complete 1.66 Mb Prochlorococcus marinus MED4 genome cloned in yeast.Nucleic acids research · 2012Article
- Functional analysis of sequence motifs involved in the polyadenylation of Trichomonas vaginalis mRNAs.Eukaryotic cell · 2012Article
- Yeast nuclear RNA processing.World journal of biological chemistry · 2012Article
- Novel protein-protein contacts facilitate mRNA 3'-processing signal recognition by Rna15 and Hrp1.Journal of molecular biology · 2010Article
- Structure of the Rna15 RRM-RNA complex reveals the molecular basis of GU specificity in transcriptional 3'-end processing factors.Nucleic acids research · 2010Article
- Systematic discovery of regulatory motifs in Fusarium graminearum by comparing four Fusarium genomes.BMC genomics · 2010Article
- Regulation of NAB2 mRNA 3'-end formation requires the core exosome and the Trf4p component of the TRAMP complex.RNA (New York, N.Y.) · 2009Article
- Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor.Nucleic acids research · 2007Article
- Grabbing the message: structural basis of mRNA 3'UTR recognition by Hrp1.The EMBO journal · 2006Article
- Global analysis of Pub1p targets reveals a coordinate control of gene expression through modulation of binding and stability.Molecular and cellular biology · 2005Article
- Functional dissection of the zinc finger and flanking domains of the Yth1 cleavage/polyadenylation factor.Nucleic acids research · 2003Article
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2 authors.
Funding
Abstract
It was previously shown that three distinct but interdependent elements are required for 3' end formation of mRNA in the yeast Saccharomyces cerevisiae: (i) the efficiency element TATATA and related sequences, which function by enhancing the efficiency of positioning elements; (ii) positioning elements, such as TTAAGAAC and AAGAA, which position the poly(A) site; and (iii) the actual site of polyadenylation. In this study, we have shown that several A-rich sequences, including the vertebrate poly(A) signal AATAAA, are also positioning elements. Saturated mutagenesis revealed that optimum sequences of the positioning element were AATAAA and AAAAAA and that this element can tolerate various extents of replacements. However, the GATAAA sequence was completely ineffective. The major cleavage sites determined in vitro corresponded to the major poly(A) sites observed in vivo. Our findings support the assumption that some components of the basic polyadenylation machinery could have been conserved among yeasts, plants, and mammals, although 3' end formation in yeasts is clearly distinct from that of higher eukaryotes.
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