ArticleMolecular and cellular biology1995
YY1 facilitates the association of serum response factor with the c-fos serum response element.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 86 citations in OpenAlex.
- Troponin: biology, molecular mechanisms, and multidimensional clinical applications.Molecular biomedicine · 2026Review
- Decreased intranuclear cardiac troponin I impairs cardiac autophagy through FOS/ATG5 in ageing hearts.Journal of cellular and molecular medicine · 2024Article
- A functional AT/G polymorphism in the 5'-untranslated region of SETDB2 in the IgE locus on human chromosome 13q14.Genes and immunity · 2015Article
- Regulation of Yin Yang 1 by Tyrosine Phosphorylation.The Journal of biological chemistry · 2015Article
- Article
- Inositol polyphosphate multikinase is a coactivator for serum response factor-dependent induction of immediate early genes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A hybrid method for the exact planted (l, d) motif finding problem and its parallelization.BMC bioinformatics · 2012Article
- The oncogenic role of Yin Yang 1.Critical reviews in oncogenesis · 2011Review
- GREAT improves functional interpretation of cis-regulatory regions.Nature biotechnology · 2010Article
- Measuring spatial preferences at fine-scale resolution identifies known and novel cis-regulatory element candidates and functional motif-pair relationships.Nucleic acids research · 2009Article
- Paracrine control of oligodendrocyte differentiation by SRF-directed neuronal gene expression.Nature neuroscience · 2009Article
- Identification of a novel cis-element exhibiting cytokinin-dependent protein binding in vitro in the 5'-region of NADPH-protochlorophyllide oxidoreductase gene in cucumber.Plant molecular biology · 2005Article
- Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin.Molecular and cellular biology · 2005Article
- Binding of serum response factor to cystic fibrosis transmembrane conductance regulator CArG-like elements, as a new potential CFTR transcriptional regulation pathway.Nucleic acids research · 2005Article
- Increased actin polymerization reduces the inhibition of serum response factor activity by Yin Yang 1.The Biochemical journal · 2002Article
- The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex.The EMBO journal · 2001Article
- Basic fibroblast growth factor activates serum response factor gene expression by multiple distinct signaling mechanisms.Molecular and cellular biology · 1999Article
- Autonomously binding protein detected on ets box of c-fos serum response element in proliferating cells.Gene expression · 1999Article
- Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway.Genes & development · 1998Article
- TFII-I enhances activation of the c-fos promoter through interactions with upstream elements.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
YY1 is a multifunctional transcription factor that acts as an activator or repressor in different contexts. YY1 binds to multiple sites in the mouse c-fos promoter, inducing at each site a sharp DNA bend. Binding of YY1 to a site situated between the cyclic AMP response element (CRE) and the TATA box bends the DNA in a way that interferes with the interaction of proteins bound at the CRE and TATA elements, resulting in repression of transcription. Here, we show that binding of YY1 to a different site in the c-fos promoter has a different result. Binding of YY1 to the c-fos serum response element (SRE) enhances the binding of serum response factor (SRF). This enhancement requires the binding of YY1 to SRE DNA. YY1 and SRF can cooccupy the SRE at least transiently. In the region of overlapping contact, YY1 contacts DNA in the major groove, while SRF contacts DNA in the minor groove. YY1 also enhances the association of SRF with the SRE in transfected insect cells. Thus, although YY1 induces similar structural changes in DNA at different binding sites, it can have distinct local effects on protein-DNA and protein-protein interactions. These data support a general role for YY1 in the building of highly organized promoter complexes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.