ArticleMolecular and cellular biology1995
Adenovirus E1A functions as a cofactor for retinoic acid receptor beta (RAR beta) through direct interaction with RAR beta.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Human papillomavirus type 16 E7 oncoprotein upregulates the retinoic acid receptor-beta expression in cervical cancer cell lines and K14E7 transgenic mice.Molecular and cellular biochemistry · 2015Article
- Cloning and analysis of the mouse follistatin promoter.Molecular biology reports · 2000Article
- The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1.Molecular and cellular biology · 1999Article
- Metabolism to a response pathway selective retinoid ligand during axial pattern formation.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- E1A represses apolipoprotein AI enhancer activity in liver cells through a pRb- and CBP-independent pathway.Nucleic acids research · 1998Article
- Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription.Molecular and cellular biology · 1998Article
- Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor.The EMBO journal · 1998Article
- A histone deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- The promoter context is a decisive factor in establishing selective responsiveness to nuclear class II receptors.The EMBO journal · 1997Article
- RIP-140 interacts with multiple nuclear receptors by means of two distinct sites.Molecular and cellular biology · 1996Article
- The dual effect of adenovirus type 5 E1A 13S protein on NF-kappaB activation is antagonized by E1B 19K.Molecular and cellular biology · 1996Article
- The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication.Wiley interdisciplinary reviews. Systems biology and medicineReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription regulation by DNA-bound activators is thought to be mediated by a direct interaction between these proteins and TATA-binding protein (TBP), TFIIB, or TBP-associated factors, although occasionally cofactors or adapters are required. For ligand-induced activation by the retinoic acid receptor-retinoid X receptor (RAR-RXR) heterodimer, the RAR beta 2 promoter is dependent on the presence of E1A or E1A-like activity, since this promoter is activated by retinoic acid only in cells expressing such proteins. The mechanism underlying this E1A requirement is largely unknown. We now show that direct interaction between RAR and E1A is a requirement for retinoic acid-induced RAR beta 2 activation. The activity of the hormone-dependent activation function 2 (AF-2) of RAR beta is upregulated by E1A, and an interaction between this region and E1A was observed, but not with AF-1 or AF-2 of RXR alpha. This interaction is dependent on conserved region III (CRIII), the 13S mRNA-specific region of E1A. Deletion analysis within this region indicated that the complete CRIII is needed for activation. The putative zinc finger region is crucial, probably as a consequence of interaction with TBP. Furthermore, the region surrounding amino acid 178, partially overlapping with the TBP binding region, is involved in both binding to and activation by AF-2. We propose that E1A functions as a cofactor by interacting with both TBP and RAR, thereby stabilizing the preinitiation complex.
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