ArticleMolecular and cellular biology1995
Widely spaced, directly repeated PuGGTCA elements act as promiscuous enhancers for different classes of nuclear receptors.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 161 citations in OpenAlex.
- Mechanisms of Feedback Regulation of Vitamin A Metabolism.Nutrients · 2022Review
- The genomic regulatory elements for estrogen receptor alpha transactivation-function-1 regulated genes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Complex sex-biased antibody responses: estrogen receptors bind estrogen response elements centered within immunoglobulin heavy chain gene enhancers.International immunology · 2019Article
- Nuclear Receptors and Neuroinflammation in Schizophrenia.Molecular neuropsychiatry · 2018Article
- The Thyroid Na+/I- Symporter: Molecular Characterization and Genomic Regulation.Molecular imaging and radionuclide therapy · 2017Article
- Signaling through retinoic acid receptors in cardiac development: Doing the right things at the right times.Biochimica et biophysica acta · 2015Review
- TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice.Journal of hepatology · 2015Article
- Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells.The Journal of cell biology · 2012Article
- The ligand-mediated nuclear mobility and interaction with estrogen-responsive elements of estrogen receptors are subtype specific.Journal of molecular endocrinology · 2012Article
- Expanding the paradigm for estrogen receptor binding and transcriptional activation.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells.Nucleic acids research · 2011Article
- DNA recognition by thyroid hormone and retinoic acid receptors: 3,4,5 rule modified.Molecular and cellular endocrinology · 2010Article
- Genomic organization of duplicated short wave-sensitive and long wave-sensitive opsin genes in the green swordtail, Xiphophorus helleri.BMC evolutionary biology · 2010Article
- Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer.Genes & development · 2010Article
- Cell-specific interaction of retinoic acid receptors with target genes in mouse embryonic fibroblasts and embryonic stem cells.Molecular and cellular biology · 2010Article
- Retinol supplements antiviral action of interferon in patients with chronic hepatitis C: a prospective pilot study.Journal of clinical biochemistry and nutrition · 2010Article
- Retinoic acid inducibility of the human PDGF-a gene is mediated by 5'-distal DNA motifs that overlap with basal enhancer and vitamin D response elements.Gene expression · 2007Article
- Induction of Hsp22 (HspB8) by estrogen and the metalloestrogen cadmium in estrogen receptor-positive breast cancer cells.Cell stress & chaperones · 2007Article
- MUC1 gene overexpressed in breast cancer: structure and transcriptional activity of the MUC1 promoter and role of estrogen receptor alpha (ERalpha) in regulation of the MUC1 gene expression.Molecular cancer · 2006Article
- Flanking sequence composition differentially affects the binding and functional characteristics of glucocorticoid receptor homo- and heterodimers.Biochemistry · 2006Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe here a novel class of cis-acting response elements for retinoid, vitamin D, and estrogen receptors which are widely spaced (10 to 200 bp) direct repeats (DRs) of the canonical 5'-AGGTCA half-site recognition motif (DR10 to DR200). In contrast to the specificity previously observed with shortly spaced DRs (DR1 to DR5), the different receptors bind promiscuously to these novel elements to activate transcription in the presence of retinoic acid (RA), vitamin D, or estrogen. The greatest RA-dependent transactivation, seen with DR15, was similar to that observed with the canonical DR5. Both RA receptors and retinoid X receptors contribute to transactivation through widely spaced DR elements. With the estrogen receptor, DR15 was one-third as efficient as the classical palindromic response element. A further increase of spacer lengths progressively decreased the efficiency of transactivation. No transactivation was seen with widely spaced DRs when the thyroid and retinoid X receptors were coexpressed in the presence of their ligands. The progesterone receptor was also unable to transactivate through a DR10 element composed of its cognate binding motifs. These results considerably extend the response element repertoire of nuclear receptors and suggest the existence of promiscuous transcriptional regulation through common response elements, as well as the possibility of receptor "cross-talk."
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