ArticleMolecular and cellular biology1995
Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesis.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 142 citations in OpenAlex.
- Relationship Between Epidermal Matrix Metalloproteinase-1 and Dermal Collagen Reduction in Skin Subjected to Chronic Sun Exposure.Journal of clinical medicine · 2025Article
- Molecular insights into proliferation and inflammation in actinic keratosis and photodynamic therapy: a comprehensive review of proliferation and inflammation markers.Contemporary oncology (Poznan, Poland) · 2025Review
- Matrix Metalloproteinase-1 Expression in Fibroblasts Accelerates Dermal Aging and Promotes Papilloma Development in Mouse Skin.The Journal of investigative dermatology · 2023Article
- Serum matrix metalloproteinase-13 as a diagnostic biomarker for cutaneous squamous cell carcinoma.BMC cancer · 2021Article
- Identification ofAntioxidants (Basel, Switzerland) · 2021Article
- Pathophysiology of Emphysema and Implications.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2016Article
- Collagenolytic matrix metalloproteinases in chronic obstructive lung disease and cancer.Cancers · 2015Review
- Matrix metalloproteinases: the gene expression signatures of head and neck cancer progression.Cancers · 2014Article
- Up-regulation of cyclooxygenase 2 and matrix metalloproteinases-2 and -9 in cutaneous squamous cell carcinoma: active role of inflammation and tissue remodeling in carcinogenesis.Annals of dermatology · 2013Article
- A functional comparison between the HER2(high)/HER3 and the HER2(low)/HER3 dimers on heregulin-β1-induced MMP-1 and MMP-9 expression in breast cancer cells.Experimental & molecular medicine · 2012Article
- Physiology and pathophysiology of matrix metalloproteases.Amino acids · 2011Review
- Site controlled transgenic mice validating increased expression from human matrix metalloproteinase (MMP-1) promoter due to a naturally occurring SNP.Matrix biology : journal of the International Society for Matrix Biology · 2009Article
- Article
- Ets1 induces dysplastic changes when expressed in terminally-differentiating squamous epidermal cells.PloS one · 2009Article
- Keratinocyte expression of MMP3 enhances differentiation and prevents tumor establishment.The American journal of pathology · 2008Article
- Inhibition of 7,12-dimethylbenzanthracene-induced skin tumors by a nutrient mixture.Medical oncology (Northwood, London, England) · 2008Article
- Article
- Epidermal growth factor receptor signaling is partially responsible for the increased matrix metalloproteinase-1 expression in ocular epithelial cells after UVB radiation.The American journal of pathology · 2005Article
- Matrix metalloproteinase inhibitors.Current oncology reports · 2004Review
- Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development.British journal of cancer · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
In a series of transgenic mice, the human tissue collagenase gene was expressed in the suprabasal layer of the skin epidermis. Visually, the mice had dry and scaly skin which upon histological analysis revealed acanthosis, hyperkeratosis, and epidermal hyperplasia. At the ultrastructural level, intercellular granular materials were absent in the transgenic skin epidermis but contact was maintained through the intact desmosomes. Despite a diversity of underlying etiologies, similar morphological hyperproliferative changes in the epidermis are observed in the human skin diseases of lamellar ichthyosis, atopic dermatitis, and psoriasis. Subsequent experiments demonstrate that when the transgenic mouse skin was treated once with an initiator (7,12-dimethyl-benz[a]anthracene) and then twice weekly with a promoter (12-O-tetradecanoylphorbol-13-acetate), there was a marked increase in tumor incidence among transgenic mice compared with that among control littermates. These experiments demonstrate that by overexpressing the highly specific proteolytic enzyme collagenase, a cascade of events leading to profound morphological changes which augment the sensitivity of the skin towards carcinogenesis is initiated in the epidermis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.