ArticleMolecular and cellular biology1995
rag-1 and rag-2 are components of a high-molecular-weight complex, and association of rag-2 with this complex is rag-1 dependent.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination.The Journal of experimental medicine · 2021Article
- Nucleolar localization of RAG1 modulates V(D)J recombination activity.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Mapping and Quantitation of the Interaction between the Recombination Activating Gene Proteins RAG1 and RAG2.The Journal of biological chemistry · 2015Article
- RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement.The Journal of experimental medicine · 2014Article
- Modeling of the RAG reaction mechanism.Cell reports · 2014Article
- CD40 interacts directly with RAG1 and RAG2 in autoaggressive T cells and Fas prevents CD40-induced RAG expression.Cellular & molecular immunology · 2013Article
- Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA.Nucleic acids research · 2013Article
- Elucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid binding.BMC biochemistry · 2011Article
- Recombination centres and the orchestration of V(D)J recombination.Nature reviews. Immunology · 2011Review
- Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.Molecular cell · 2010Article
- Article
- Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase.Molecular immunology · 2009Article
- Article
- Evidence for Ku70/Ku80 association with full-length RAG1.Nucleic acids research · 2008Article
- A variable immunoreceptor in a subpopulation of human neutrophils.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Overlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells.Molecular and cellular biology · 2003Article
- Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination.Genes & development · 2002Article
- RAG1 and RAG2 in V(D)J recombination and transposition.Immunologic research · 2001Review
- Mmip-2, a novel RING finger protein that interacts with mad members of the Myc oncoprotein network.Oncogene · 1999Article
- Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking.Molecular and cellular biology · 1999Article
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Authors and funding
2 authors.
Funding
Abstract
Despite the essential and synergistic functions of the rag-1 and rag-2 proteins in V(D)J recombination and lymphocyte development, little is known about the biochemical properties of the two proteins. We have developed cell lines expressing high levels of the rag proteins and specific, sensitive immunological reagents for their detection, and we have examined the physical properties of the rag proteins in vitro and their subcellular localizations in vivo. rag-1 is tightly associated with nuclear structures, requires a high salt concentration to maintain its solubility, and is a component of large, heterogeneously sized complexes. Furthermore, the presence of rag-1 alters the behavior of rag-2, conferring on it properties similar to those of rag-1 and changing its distribution in the nucleus. We demonstrate that rag-1 and rag-2 are present in the same complex by coimmunoprecipitation, and we provide evidence that these complexes contain more molecules of rag-2 than of rag-1. The demonstration of intracellular complexes containing rag-1 and rag-2 raises the possibility that interaction between these proteins is necessary for their biological function.
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