ArticleMolecular and cellular biology1995
DNA methylation associated with repeat-induced point mutation in Neurospora crassa.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 98 citations in OpenAlex.
- Symmetric adenine methylation is an essential DNA modification in the early-diverging fungus Rhizopus microsporus.Nature communications · 2025Article
- DNA methylation plays important roles in lifestyle transition of Arthrobotrys oligospora.IET systems biology · 2024Article
- The massive 340 megabase genome of Anisogramma anomala, a biotrophic ascomycete that causes eastern filbert blight of hazelnut.BMC genomics · 2024Article
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- H3K56 deacetylation and H2A.Z deposition are required for aberrant heterochromatin spreading.Nucleic acids research · 2022Article
- Comparative analysis of genome-wide DNA methylation inEpigenetics · 2020Article
- Repeat-induced point mutation in Neurospora crassa causes the highest known mutation rate and mutational burden of any cellular life.Genome biology · 2020Article
- Article
- Diversity of cytosine methylation across the fungal tree of life.Nature ecology & evolution · 2019Article
- Analysis of Repeat Induced Point (RIP) Mutations inGenetics · 2019Article
- Epigenetic regulation of development and pathogenesis in fungal plant pathogens.Molecular plant pathology · 2017Review
- Massive Expansion of Gypsy-Like Retrotransposons in Microbotryum Fungi.Genome biology and evolution · 2017Article
- Article
- The landscape of transposable elements in the finished genome of the fungal wheat pathogen Mycosphaerella graminicola.BMC genomics · 2014Article
- Neurospora crassa, a model system for epigenetics research.Cold Spring Harbor perspectives in biology · 2013Review
- Convergent transcription induces dynamic DNA methylation at disiRNA loci.PLoS genetics · 2013Article
- H2B- and H3-specific histone deacetylases are required for DNA methylation in Neurospora crassa.Genetics · 2010Article
- Confining euchromatin/heterochromatin territory: jumonji crosses the line.Genes & development · 2010Review
- The DMM complex prevents spreading of DNA methylation from transposons to nearby genes in Neurospora crassa.Genes & development · 2010Article
- Ubiquitin ligase components Cullin4 and DDB1 are essential for DNA methylation in Neurospora crassa.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Repeat-induced point mutation (RIP) is a process that efficiently detects DNA duplications prior to meiosis in Neurospora crassa and peppers them with G:C to A:T mutations. Cytosine methylation is typically associated with sequences affected by RIP, and methylated cytosines are not limited to CpG dinucleotides. We generated and characterized a collection of methylated and unmethylated amRIP alleles to investigate the connection(s) between DNA methylation and mutations by RIP. Alleles of am harboring 84 to 158 mutations in the 2.6-kb region that was duplicated were heavily methylated and triggered de novo methylation when reintroduced into vegetative N. crassa cells. Alleles containing 45 and 56 mutations were methylated in the strains originally isolated but did not become methylated when reintroduced into vegetative cells. This provides the first evidence for de novo methylation in the sexual cycle and for a maintenance methylation system in Neurospora cells. No methylation was detected in am alleles containing 8 and 21 mutations. All mutations in the eight primary alleles studied were either G to A or C to T, with respect to the coding strand of the am gene, suggesting that RIP results in only one type of mutation. We consider possibilities for how DNA methylation is triggered by some sequences altered by RIP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.