ArticleMolecular and cellular biology1995
Structure-function relationships of the yeast cyclin-dependent kinase Pho85.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Acid phosphatases of budding yeast as a model of choice for transcription regulation research.Enzyme research · 2011Article
- The yeast Pho80-Pho85 cyclin-CDK complex has multiple substrates.Current genetics · 2004Article
- Identification of p21-activated kinase specificity determinants in budding yeast: a single amino acid substitution imparts Ste20 specificity to Cla4.Molecular and cellular biology · 2003Article
- Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Substrate targeting of the yeast cyclin-dependent kinase Pho85p by the cyclin Pcl10p.Molecular and cellular biology · 1999Article
- Activating phosphorylation of the Kin28p subunit of yeast TFIIH by Cak1p.Molecular and cellular biology · 1999Article
- Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 1998Review
- Cak1 is required for Kin28 phosphorylation and activation in vivo.Molecular and cellular biology · 1998Article
- A cyclin-dependent kinase family member (PHOA) is required to link developmental fate to environmental conditions in Aspergillus nidulans.The EMBO journal · 1998Article
- Article
- Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility.Molecular and cellular biology · 1997Article
- Pho85p, a cyclin-dependent protein kinase, and the Snf1p protein kinase act antagonistically to control glycogen accumulation in Saccharomyces cerevisiae.Molecular and cellular biology · 1996Article
- Deletion of the gene encoding the cyclin-dependent protein kinase Pho85 alters glycogen metabolism in Saccharomyces cerevisiae.Genetics · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The PHO85 gene of Saccharomyces cerevisiae encodes a cyclin-dependent kinase involved in both transcriptional regulation and cell cycle progression. Although a great deal is known concerning the structure, function, and regulation of the highly homologous Cdc28 protein kinase, little is known concerning these relationships in regard to Pho85. In this study, we constructed a series of Pho85-Cdc28 chimeras to map the region(s) of the Pho85 molecule that is critical for function of Pho85 in repression of acid phosphatase (PHO5) expression. Using a combination of site-directed and ethyl methanesulfonate-induced mutagenesis, we have identified numerous residues critical for either activation of the Pho85 kinase, interaction of Pho85 with the cyclin-like molecule Pho80, or substrate recognition. Finally, analysis of mutations analogous to those previously identified in either Cdc28 or cdc2 of Schizosaccharomyces pombe suggested that the inhibition of Pho85-Pho80 activity in mechanistically different from that seen in the other cyclin-dependent kinases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.