ArticleMolecular and cellular biology1995
The DNA-binding properties of two heat shock factors, HSF1 and HSF3, are induced in the avian erythroblast cell line HD6.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 110 citations in OpenAlex.
- Adaptation to heat stress by diversification of the vertebrate heat shock transcription factor family.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- HSF1 is required for cellular adaptation to daily temperature fluctuations.Scientific reports · 2024Article
- Hijacking Cellular Stress Responses to Promote Lifespan.Frontiers in aging · 2022Review
- Heat shock proteins with an emphasis on HSP 60.Molecular biology reports · 2021Review
- Co-enzyme Q10 and acetyl salicylic acid enhance Hsp70 expression in primary chicken myocardial cells to protect the cells during heat stress.Molecular and cellular biochemistry · 2017Article
- Article
- Dual neuroprotective pathways of a pro-electrophilic compound via HSF-1-activated heat-shock proteins and Nrf2-activated phase 2 antioxidant response enzymes.Journal of neurochemistry · 2011Article
- Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation.Molecular biology of the cell · 2011Article
- Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT.The EMBO journal · 2010Article
- A novel mouse HSF3 has the potential to activate nonclassical heat-shock genes during heat shock.Molecular biology of the cell · 2010Article
- Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses.The Journal of biological chemistry · 2008Article
- Up-regulation of the clusterin gene after proteotoxic stress: implication of HSF1-HSF2 heterocomplexes.The Biochemical journal · 2006Article
- HSF4 is required for normal cell growth and differentiation during mouse lens development.The EMBO journal · 2004Article
- Activation of heat shock genes is not necessary for protection by heat shock transcription factor 1 against cell death due to a single exposure to high temperatures.Molecular and cellular biology · 2003Article
- Cell cycle transition under stress conditions controlled by vertebrate heat shock factors.The EMBO journal · 2001Article
- Plants contain a novel multi-member class of heat shock factors without transcriptional activator potential.Plant molecular biology · 2000Article
- Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1.The EMBO journal · 2000Article
- Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway.Molecular and cellular biology · 1998Article
- The tomato Hsf system: HsfA2 needs interaction with HsfA1 for efficient nuclear import and may be localized in cytoplasmic heat stress granules.Molecular and cellular biology · 1998Article
- Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance.The EMBO journal · 1998Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Avian cells express three heat shock transcription factor (HSF) genes corresponding to a novel factor, HSF3, and homologs of mouse and human HSF1 and HSF2. Analysis of the biochemical and cell biological properties of these HSFs reveals that HSF3 has properties in common with both HSF1 and HSF2 and yet has features which are distinct from both. HSF3 is constitutively expressed in the erythroblast cell line HD6, the lymphoblast cell line MSB, and embryo fibroblasts, and yet its DNA-binding activity is induced only upon exposure of HD6 cells to heat shock. Acquisition of HSF3 DNA-binding activity in HD6 cells is accompanied by oligomerization from a non-DNA-binding dimer to a DNA-binding trimer, whereas the effect of heat shock on HSF1 is oligomerization of an inert monomer to a DNA-binding trimer. Induction of HSF3 DNA-binding activity is delayed compared with that of HSF1. As occurs for HSF1, heat shock leads to the translocation of HSF3 to the nucleus. HSF exhibits the properties of a transcriptional activator, as judged from the stimulatory activity of transiently overexpressed HSF3 measured by using a heat shock element-containing reporter construct and as independently assayed by the activity of a chimeric GAL4-HSF3 protein on a GAL4 reporter construct. These results reveal that HSF3 is negatively regulated in avian cells and acquires DNA-binding activity in certain cells upon heat shock.
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